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Nickel(II)+p-toluenesulfonate
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Nickel(II)+p-toluenesulfonate
Catalog Number:
(10750-330)
Supplier:
Prosci
Description:
MARCH8 Antibody: MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
Catalog Number:
(10664-316)
Supplier:
Bioss
Description:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Catalog Number:
(10664-310)
Supplier:
Bioss
Description:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Catalog Number:
(89149-728)
Supplier:
Enzo Life Sciences
Description:
Triterpenoid. Antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. Inhibits NF-κB activation via inhibition of IKKα or IKKβ. Inhibits induction of inducible nitric oxide synthase (iNOS; NOS II). Shows in vitro antimalarial and insecticidal activity. Induces mitochondrial cell death. Has antiproliferative, antifungal and antiviral properties. Potent and reversible monoacylglycerol lipase (MGL) inhibitor.
Catalog Number:
(10238-584)
Supplier:
Bioss
Description:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
Catalog Number:
(10239-256)
Supplier:
Bioss
Description:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
Supplier:
BeanTown Chemical
Description:
CAS: 7647-01-0; EC No: 231-595-7; MDL No: MFCD00011324
UN No: UN1789; Haz Class: 8; Packing Group: II
Liquid; Molecular Formula: HCl; MW: 36.46
Supplier:
Tonbo Biosciences
Description:
The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
Catalog Number:
(10102-072)
Supplier:
Prosci
Description:
ZXDA contains 10 C2H2-type zinc fingers. It belongs to the ZXD family. ZXDA cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
Catalog Number:
(10404-690)
Supplier:
Bioss
Description:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Supplier:
BeanTown Chemical
Description:
CAS: 12030-49-8; EC No: 234-743-9; MDL No: MFCD00011065
UN No: UN1479; Haz Class: 5.1; Packing Group: II
Powder; Molecular Formula: IrO2; MW: 224.21
Supplier:
AVIDITY SCIENCE
Description:
Two-In-One system provides DI or RO water to a storage tank, and capable of dispensing Type 1 and Type 2 or Type 3 water from dispense guns (depending on model variation).
Supplier:
BeanTown Chemical
Description:
CAS: 107-06-2; EC No: 203-458-1; MDL No: MFCD00000963; RTECS: KI0525000
UN No: UN1184; Haz Class: 3 (6.1); Packing Group: II
Liquid; Linear Formula: ClCH2CH2Cl ; Molecular Formula: C2H4Cl2; MW: 98.96
Melting Point: -35°; Boiling Point: 83°; Flash point: 13°C (55°F)
Density (g/mL): 1.256; Refractive Index: 1.444
Catalog Number:
(BT128565-100G)
Supplier:
BeanTown Chemical
Description:
CAS: 87-62-7; EC No: 201-758-7; MDL No: MFCD00007747; RTECS: ZE9275000
UN No: UN1711; Haz Class: 6.1; Packing Group: II
Liquid; Molecular Formula: C8H11N; MW: 121.18
Melting Point: 10-12°; Boiling Point: 214°/739 mmHg; Flash point: 91°C (196°F)
Density (g/mL): 0.984; Refractive Index: 1.560
Supplier:
Biotium
Description:
Cytokeratin 7 Monoclonal antibody, Clone: OV-TL12/30, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: OTN 11, ovarian carcinoma cell line, Synonyms: CK-7, K2C7, Keratin 55K Type II, Application: IF, IHC, Size: 100uL
Catalog Number:
(71130-004)
Supplier:
Cambridge Diagnostic Products
Description:
The Fastest and Most Reliable Differential Stain Available
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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