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Nickel(II)+p-toluenesulfonate
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Nickel(II)+p-toluenesulfonate
Catalog Number:
(10461-036)
Supplier:
Bioss
Description:
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
Catalog Number:
(10262-030)
Supplier:
Bioss
Description:
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).
Catalog Number:
(10262-028)
Supplier:
Bioss
Description:
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).
Catalog Number:
(103010-484)
Supplier:
Anaspec Inc
Description:
Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease.
Recombinant rat pro-renin was expressed in HEK cells. Purified enzyme was converted to the active renin by tryptic activation followed by removal of trypsin. The molecular mass of active rat renin is approximately 40 kDa. The activity of enzyme can be measured in FRET-based assays
Supplier:
BeanTown Chemical
Description:
CAS: 140-89-6; EC No: 205-439-3; MDL No: MFCD00004931; RTECS: FG1575000
UN No: UN3342; Haz Class: 4.2; Packing Group: II
Solid; Linear Formula: CH3CH2OCSSK; Molecular Formula: C3H5KOS2; MW: 160.3
Melting Point: 210° (decomposes); Flash point: 96°C (205°F)
Density (g/mL): 1.558
Supplier:
BeanTown Chemical
Description:
CAS: 627-19-0; EC No: 210-987-1; MDL No: MFCD00009469
UN No: UN3295; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3CH2CH2C≡CH; Molecular Formula: C5H8; MW: 68.12
Melting Point: -106°; Boiling Point: 40°; Flash point: -20°C (-4°F)
Density (g/mL): 0.691; Refractive Index: 1.385
Supplier:
BeanTown Chemical
Description:
CAS: 7646-78-8; EC No: 231-588-9; MDL No: MFCD00011242; RTECS: XP8750000
UN No: UN1827; Haz Class: 8; Packing Group: II
Liquid; Linear Formula: SnCl4; MW: 260.52
Melting Point: -33°; Boiling Point: 114°
Density (g/mL): 2.226; Refractive Index: 1.512
Air Sensitive, Moisture Sensitive
Catalog Number:
(76100-522)
Supplier:
Bioss
Description:
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
Supplier:
BeanTown Chemical
Description:
CAS: 18791-02-1; EC No: 242-575-2; MDL No: MFCD00000712; RTECS: UG6657500
UN No: UN3265; Haz Class: 8; Packing Group: II
Liquid; Molecular Formula: C3H3Br2ClO; MW: 250.32
Boiling Point: 191-193°; Flash point: 66°C (151°F)
Density (g/mL): 2.181; Refractive Index: 1.542
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 67-64-1; EC No: 200-662-2; MDL No: MFCD00008765; RTECS: AL3150000
UN No: UN1090; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3COCH3; MW: 58.08
Melting Point: -94°; Boiling Point: 56°; Flash point: -17°C (1°F)
Density (g/mL): 0.791; Refractive Index: 1.359
Catalog Number:
(BT223560-25G)
Supplier:
BeanTown Chemical
Description:
CAS: 1455-13-6; EC No: 215-933-0; MDL No: MFCD00044213
UN No: UN1230; Haz Class: 3; Packing Group: II
Liquid; Molecular Formula: CH3OD; MW: 33.05
Melting Point: -98°; Boiling Point: 65.5°; Flash point: 11°C (54°F)
Density (g/mL): 0.813; Refractive Index: 1.327
Catalog Number:
(10434-720)
Supplier:
Bioss
Description:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor.
Catalog Number:
(10764-344)
Supplier:
Prosci
Description:
The WM-15 monoclonal antibody specifically reacts with human CD13, 150-170 type II transmembrane ectoenzyme also named aminopeptidase N and gp150. It is expressed by granulocytes and monocytes, epithelial cells, and endothelial cells. CD13 plays a role in the terminal degradation of peptides, antigen processing, and chemokine cleavage, and cellular adhesion.
Catalog Number:
(10764-342)
Supplier:
Prosci
Description:
The WM-15 monoclonal antibody specifically reacts with human CD13, 150-170 type II transmembrane ectoenzyme also named aminopeptidase N and gp150. It is expressed by granulocytes and monocytes, epithelial cells, and endothelial cells. CD13 plays a role in the terminal degradation of peptides, antigen processing, and chemokine cleavage, and cellular adhesion.
Supplier:
BeanTown Chemical
Description:
CAS: 598-32-3; EC No: 209-929-8; MDL No: MFCD00004543; RTECS: EM9275000
UN No: UN1986; Haz Class: 3 (6.1); Packing Group: II
Liquid; Molecular Formula: C4H8O; MW: 72.11
Boiling Point: 96-97°; Flash point: 16°C (61°F)
Density (g/mL): 0.832; Refractive Index: 1.415
Catalog Number:
(10338-004)
Supplier:
Bioss
Description:
L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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