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Pentafluorophenyl+isothiocyanate
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Pentafluorophenyl+isothiocyanate
Catalog Number:
(10467-862)
Supplier:
Bioss
Description:
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
Catalog Number:
(10406-956)
Supplier:
Bioss
Description:
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009].
Catalog Number:
(10397-310)
Supplier:
Bioss
Description:
CARF was first cloned as a novel binding partner of ARF from a yeast interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
Catalog Number:
(10461-038)
Supplier:
Bioss
Description:
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
Catalog Number:
(10389-742)
Supplier:
Bioss
Description:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Supplier:
Biolegend
Description:
FITC anti-human Galectin-9 [9M1-3]; Isotype: Mouse IgG1, κ; Reactivity: Human, African Green, Baboon, Cynomolgus; Apps: ICFC, FC; Size: 100 tests
Catalog Number:
(10409-452)
Supplier:
Bioss
Description:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP free TAFII complex (TFTC). TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.
Supplier:
Biolegend
Description:
FITC anti-mouse CD80 [16-10A1]; Isotype: Armenian Hamster IgG; Reactivity: Mouse, Cross-Reactivity: Dog (Canine); Apps: FC; Size: 500 μg
Catalog Number:
(114706-BL)
Supplier:
Biolegend
Description:
FITC anti-mouse H-2Kd/H-2Dd [34-1-2S]; Isotype: Mouse (C3H) IgG2a, κ; Reactivity: Cross-reacts with H-2Kb, s, r, q, p; Apps: FC; Size: 500 μg
Supplier:
Biolegend
Description:
FITC anti-mouse I-Ad [39-10-8]; Isotype: Mouse (C3H.SW) IgG3, κ; Reactivity: Mouse d haplotype, Does not cross-react with other haplotypes (e.g., a, b, k, p, q, s); Apps: FC; Size: 500 μg
Supplier:
Biolegend
Description:
FITC anti-mouse CD90.2 (Thy1.2) [53-2.1]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Does not react with Thy-1.1 (CD90.1); Apps: FC; Size: 500 μg
Catalog Number:
(10229-976)
Supplier:
Bioss
Description:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Catalog Number:
(10453-578)
Supplier:
Bioss
Description:
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.Mainly expressed in tissues that synthesize triglycerides.
Catalog Number:
(10432-268)
Supplier:
Bioss
Description:
C1 Inactivator is a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Catalog Number:
(10460-958)
Supplier:
Bioss
Description:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Catalog Number:
(10450-730)
Supplier:
Bioss
Description:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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