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2-[(4-Pyridinylmethyl)amino]isonicotinic+acid
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2-[(4-Pyridinylmethyl)amino]isonicotinic+acid
Catalog Number:
(76083-130)
Supplier:
Bioss
Description:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
Catalog Number:
(76083-128)
Supplier:
Bioss
Description:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
Catalog Number:
(10300-158)
Supplier:
Bioss
Description:
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interacts with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling, along with involvement in many pathological conditions. GPR31 (G-protein coupled receptor 31) is a 319 amino acid orphan receptor that localizes to the cell membrane. GPR31 shares 25-33% homology with members of the chemokine, purino and somatostatin receptor gene families.
Catalog Number:
(101925-376)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 063233-500MG , MDL Number: MFCD00249609
Catalog Number:
(100196-860)
Supplier:
Strem Chemicals Inc
Description:
Designed for working with air-sensitive materials, these Suba Seal® closures have a turnover flange molded to grip the outside of the container neck, promoting a double seal in conjunction with the annular serrations on the hollow plug.
Supplier:
Lakeland
Description:
High Performance FR Lightweight Pants feature 8 oz. Westex® UltraSoft® fabric that has a unique basketweave blend and provides increased mobility and comfort, making them an excellent choice for arc flash and flash fire protection.
Catalog Number:
(101880-370)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 047507-1G , MDL Number: MFCD07369415
Catalog Number:
(101818-344)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 024572-500MG , MDL Number: MFCD00173793
Catalog Number:
(101928-644)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 064922-500MG , MDL Number: MFCD03713023
Catalog Number:
(470003-340)
Supplier:
EATON OFFICE SUPPLY
Description:
Alliance® industrial rubber band with mid-range rubber content, high tensile strength and good firm strength.
Catalog Number:
(BJ11213-6X1KG)
Supplier:
Honeywell Research Chemicals
Description:
Ammonium hydrogen carbonate 99-101%, Puriss., meets analytical specification of BP, Ph. Eur., E503, Fluka™
Catalog Number:
(22221-420)
Supplier:
Metro
Description:
Shelves provide efficient storage and transport of standard component reels.
Supplier:
TCI America
Description:
CAS Number: 537-73-5
MDL Number: MFCD00004391 Molecular Formula: C10H10O4 Molecular Weight: 194.19 Purity/Analysis Method: >98.0% (T,HPLC) Form: Crystal Melting point (°C): 228
Catalog Number:
(89151-596)
Supplier:
Enzo Life Sciences
Description:
DNA methyltransferase inhibitor
Catalog Number:
(RL209-403-B50)
Supplier:
Rockland Immunochemical
Description:
This purified antibody has been tested for use in ELISA and western blotting. By western blot a band approximately 18 kDa in size corresponding to mature human IL-32a Protein is expected in the appropriate cell lysate or extract.
Catalog Number:
(101827-516)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 029121-500MG , MDL Number: MFCD03422613
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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