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Sodium+methotrexate
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Sodium+methotrexate
Catalog Number:
(76117-968)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Catalog Number:
(75928-370)
Supplier:
Rockland Immunochemical
Description:
Lyophilized Gamma Globulin Fraction
Catalog Number:
(77438-804)
Supplier:
Bioss
Description:
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Catalog Number:
(76422-446)
Supplier:
Biolegend
Description:
CD127, Monoclonal Antibody, Clone: S18006K, Host: Rat, Species Reactivity: Mouse, Isotype: IgG, Immunogen: mouse IL7R-transfectants, Other Names: IL-7 receptor A chain, IL-7RA, Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide, Size: 500 uG
Catalog Number:
(TCF0138-025G)
Supplier:
TCI America
Description:
CAS Number: 915-67-3
MDL Number: MFCD00004076 Molecular Formula: C20H14N2O10S3 Molecular Weight: 604.46 Form: Powder Color: Red Melting point (°C): 220 Lambda max.: 521 nm (H2O)
Catalog Number:
(76040-240)
Supplier:
Tonbo Biosciences
Description:
Goat anti-Rabbit IgG, secondary antibody, conjugated toSureLight® R-Phycoerythrin
Catalog Number:
(10366-014)
Supplier:
Bioss
Description:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
Catalog Number:
(RLMB-018)
Supplier:
Rockland Immunochemical
Description:
SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, describes a technique widely used in biochemistry to separate proteins according to their electrophoretic mobility (a function of the length of a polypeptide chain and its charge) and no other physical feature
Catalog Number:
(RL612-1106)
Supplier:
Rockland Immunochemical
Description:
Anti-Rat IgA antibody is suitable for Elisa, Western Blots and immunochemistry. Antibody should be optimized by the end user for specific conditions of reactivity.
Catalog Number:
(10432-402)
Supplier:
Bioss
Description:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Catalog Number:
(76422-300)
Supplier:
Biolegend
Description:
CD66b, Recombinant Monoclonal Antibody, Clone: QA17A51, Host: Mouse, Species Reactivity: Human, Isotype: IgG1, K, Conjugate: PE/Cyanine7, Other Names: CD67, CGM6, NCA-95, CEACAM8, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide 0.2% BSA, Size: 25 Tests
Supplier:
TCI America
Description:
CAS Number: 1655-45-4
MDL Number: MFCD00004092 Molecular Formula: C10H8O6S2 Molecular Weight: 332.25 Purity/Analysis Method: >90.0% (T) Form: Crystal
Catalog Number:
(76510-078)
Supplier:
Genscript
Description:
The product is specific for durvalumab.
Supplier:
Rockland Immunochemical
Description:
Lyophilized Gamma Globulin Fraction
Supplier:
Biolegend
Description:
CD72, Monoclonal Antibody, Clone: 3F3, Host: Mouse, Species Reactivity: Human, Isotype: IgG2b, K, Conjugate: PE, Immunogen: Human lymphocytes, Other Names: Lyb-2, Ly-19.2, Ly-32.2, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide and 0.2%BSA, Size: 100 Tests
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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