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4-(1H-Tetrazol-5-yl)benzoic+acid
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4-(1H-Tetrazol-5-yl)benzoic+acid
Supplier:
GE Healthcare - HyClone
Description:
Balanced salt solution used for multiple cell culture applications (powder form).
Catalog Number:
(89269-802)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to SLC37A4 (N-terminal)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Phytic acid 50% (w/w) in aqueous solution
Catalog Number:
(89273-626)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [7G10] to GPI
Catalog Number:
(89270-130)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to GFPT2 (Middle)
Supplier:
PeproTech, Inc.
Description:
Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and, to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively. The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating protein arises from the action of an as yet unidentified protease, which cleaves transmembrane Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone-derived hormone that acts in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally abolished. Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa.
Catalog Number:
(89291-202)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to AGPAT4
Catalog Number:
(89292-330)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to CI-MPR
Catalog Number:
(10071-930)
Supplier:
Prosci
Description:
Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Catalog Number:
(10408-978)
Supplier:
Bioss
Description:
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs).
Catalog Number:
(89277-898)
Supplier:
Genetex
Description:
Rabbit Polyclonal to Human Sphingolipid Receptor Edg6 / S1P4
Catalog Number:
(89288-540)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to SGPP2 (C-terminal)
Catalog Number:
(89267-016)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to RPIA (N-terminal)
Catalog Number:
(75780-014)
Supplier:
ACL Staticide
Description:
This high-performance floor stripper removes multiple coats of wax or synthetic floor finishes
Catalog Number:
(89291-360)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to AGPAT5
Supplier:
BeanTown Chemical
Description:
CAS: 7722-88-5; EC No: 231-767-1; MDL No: MFCD00003513; RTECS: UX7350000
Granular; Linear Formula: Na4P2O7; MW: 265.90
Melting Point: 622-985°
Density (g/mL): 2.534
Hygroscopic
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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