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2,4-Difluoro-3-(methoxymethyl)benzoic+acid
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2,4-Difluoro-3-(methoxymethyl)benzoic+acid
Catalog Number:
(77006-114)
Supplier:
AMBEED, INC
Description:
m-Tolylmethanesulfonyl chloride, Purity: 95%, CAS number: 53531-68-3, Appearance: White to Yellow Solid, Storage: Inert atmosphere, 2-8C, Size: 1G
Supplier:
AMBEED, INC
Description:
Strontium chloride, Purity: anhydrous, 99.5% metals basis, CAS Number: 10476-85-4, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 500G
Supplier:
APOLLO SCIENTIFIC
Description:
Benzenesulfonyl chloride 99%
Supplier:
AMBEED, INC
Description:
Piperidine-1-sulfonyl chloride 95%
Catalog Number:
(TS40507-0250)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
3-(Chlorosulfonyl)benzoyl chloride 98%
Supplier:
AMBEED, INC
Description:
2,3,5-Triphenyltetrazolium chloride (TTC) 98%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
N,N-Diisopropylcarbamoyl chloride 98%
Supplier:
AMBEED, INC
Description:
2-Fluorobenzoyl chloride 95%
Catalog Number:
(IC15251580)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
(4-Chlorophenyl)acetyl chloride 96%
Catalog Number:
(10235-858)
Supplier:
Bioss
Description:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Catalog Number:
(10302-428)
Supplier:
Bioss
Description:
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF1B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Supplier:
APOLLO SCIENTIFIC
Description:
3-Chloro-5-fluorobenzoyl chloride
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Chromium(III) chloride hexahydrate 98%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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