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Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 049865-2.5G , MDL Number: MFCD13560267
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 049845-2.5G , MDL Number: MFCD13560247
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 049862-2.5G , MDL Number: MFCD13560264
Catalog Number:
(75789-840)
Supplier:
Prosci
Description:
Mouse Il10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV).Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Although human and mouse IL-10 are 81% identical at the nucleotide and amino acid level, mouse IL-10 is species-specific and does not act on human cells. Interestingly, Human IL-10 is active on mouse cells.
Catalog Number:
(101923-222)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 062065-500MG , MDL Number: MFCD12197941
Catalog Number:
(101815-632)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 023249-500MG , MDL Number: MFCD12026504
Catalog Number:
(101815-282)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 023067-500MG , MDL Number: MFCD10687215
Catalog Number:
(101815-662)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 023264-500MG , MDL Number: MFCD11100496
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045554-5G , MDL Number: MFCD00170203
Catalog Number:
(10075-378)
Supplier:
Prosci
Description:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
Catalog Number:
(10075-376)
Supplier:
Prosci
Description:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
Catalog Number:
(76100-052)
Supplier:
Bioss
Description:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
Catalog Number:
(101925-688)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 063425-500MG , MDL Number: MFCD07658063
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 050446-500MG , MDL Number: MFCD13560847
Catalog Number:
(101927-154)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 064152-500MG , MDL Number: MFCD07787191
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 049890-2.5G , MDL Number: MFCD13560292
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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