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Adenosine+5'-monophosphate+monohydrate
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Adenosine+5'-monophosphate+monohydrate
Catalog Number:
(89162-048)
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome.A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (now referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing.
Supplier:
Spectrum Chemicals
Description:
Saccharin Sodium, Dihydrate, Powder, USP is a pharmaceutical grade substance whose most common use is as an artificial sweetener. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Catalog Number:
(102882-812)
Supplier:
R&D Systems
Description:
Mouse CD3 Phycoerythrin, Monoclonal, Host: Rat, Clone NO: 17A2, Isotype: IgG2B, Immunogen: T cell hybridoma D1, Flow Cytometry, 25 Tests
Catalog Number:
(102882-792)
Supplier:
R&D Systems
Description:
Mouse CD3 Allophycocyanin, Monoclonal, Host: Rat, Clone NO: 17A2, Isotype: IgG2B, Immunogen: T cell hybridoma D1, Flow Cytometry, 25 Tests
Catalog Number:
(10447-338)
Supplier:
Bioss
Description:
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Catalog Number:
(76516-694)
Supplier:
Eppendorf
Description:
Eppendorf epT.I.P.S.® Box 2.0, available with 'Eppendorf Quality' pipette tips or as an empty box, improves lab efficiency with innovative TwinLid® technology, enhanced stackability, and superior ergonomics for safe and organized pipetting.
Catalog Number:
(89277-754)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to P2Y8 Purity: Immunogen affinity purified Species Reactivity: Human Tested Applications: IHC-P Pkg Size: 25 ug
Supplier:
Analytik Jena US
Description:
High performance 25 watt UV tubes for high fluorescence and sensitivity on stained gels
Catalog Number:
(10758-280)
Supplier:
Biolegend
Description:
Brilliant Violet 421™ anti-human CD105 [43A3]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 25 tests
Supplier:
ACROBIOSYSTEMS INC MS
Description:
DNP monoclonal antibody, Species Reactivity: Human, Host: HEK293 cell, Molecular Weight: 50 and 25 kDa for the heavy and light chains, respectively (150kDa), Isotype: IgG1 (N297A), Kappa LC, Storage: Avoid repeated freeze-thaw cycles, Storage: lyophilized state at -20 deg C or lower, Size: 1mg
Catalog Number:
(102987-178)
Supplier:
Adipogen
Description:
Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization.
Catalog Number:
(102882-796)
Supplier:
R&D Systems
Description:
Mouse CD3 PerCP, Monoclonal, Host: Rat, Clone NO: 17A2, Isotype: IgG2B, Immunogen: T cell hybridoma D1, Flow Cytometry, 25 Tests
Catalog Number:
(102882-578)
Supplier:
R&D Systems
Description:
Human CD4 Fluorescein, Monoclonal, Host: Mouse, Clone NO: 11830, Isotype: IgG2A, Immunogen: Recombinant Human CD4. Flow Cytometry, 25 Tests
Catalog Number:
(89277-410)
Supplier:
Genetex
Description:
Monoclonal Antibody to CD11a (Human) Phycoerythrin (PE) conjugated
Supplier:
Labconco
Description:
FreeZone® Triad® Benchtop Freeze Dryers are designed for multiple types of lyophilization: flask, bulk and stoppering vials. With the ability to freeze dry samples in so many different forms, the Triad’s versatility and compact design make it perfect for busy labs. Now with Lyo-Works™ OS the Triad is smarter than ever, making freeze drying even challenging samples easy.
Catalog Number:
(89162-052)
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. Based on sequence similarity, all fourteen 20S proteasomal subunit sequences may be classified into two groups, α and β, each group having distinct structural and functional roles. The α-subunits comprise the outer rings and the β-subunits the inner rings of the 20S proteasome. Observations of the eukaryotic proteasome and analysis of subunit sequences indicate that each ring contains seven different subunits (α7β7β7α7) with a member of each sub-family represented in each particle. Each subunit is located in a unique position within the α- or β-rings. 120S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The hybridoma secreting the antibody to subunits HC2, HC3, HC8, HC9, Iota and Zeta was generated by fusion of spenocytes from Balb/c mice which had recieved repeated immunisation with dinitrophenylated proteasomes.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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