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Tris(4-aminophenyl)methane
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Tris(4-aminophenyl)methane
Supplier:
Adipogen
Description:
Beclin-1 (Bcl-2 interacting coiled-coil protein; ATG6) is a multifunctional protein, well-known as a key regulator of autophagy and required for the initiation step in autophagosome formation. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP3R, PINK and survivin) to regulate the lipid kinase PI3K protein and promote formation of PIK3C3/VPS34-containing complexes. These interactions induce autophagy, which is a process of programmed cell survival increased during periods of cell stress and extinguished during the cell cycle. Furthermore, beclin-1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, infection, tumorigenesis, aging and cell death. Beclin-1 is tightly regulated by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications and protein-protein interactions. Multiple diseases are associated with deficiency or malfunction of beclin-1, including cancer and neurodegeneration.
Catalog Number:
(101095-616)
Supplier:
USP
Description:
(500 mg)
Catalog Number:
(75929-256)
Supplier:
Rockland Immunochemical
Description:
IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (1). IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer (2). IRS1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, AKT/PKB Pathway, Cancer, Cellular Stress, and ERK/MAPK Pathway research.
Catalog Number:
(89160-364)
Supplier:
Enzo Life Sciences
Description:
Nicotinamide, the water-soluble amide of nicotinic acid, is a component of the two most important coenzymes-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Nicotinamide is involved in numerous oxidation-reduction reactions in mammalian biological systems acting as an antioxidant.
Catalog Number:
(75929-258)
Supplier:
Rockland Immunochemical
Description:
IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (1). IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer (2). IRS1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, AKT/PKB Pathway, Cancer, Cellular Stress, and ERK/MAPK Pathway research.
Catalog Number:
(75929-906)
Supplier:
Rockland Immunochemical
Description:
MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by p53, as part of an autoregulatory negative feedback loop (1). Overexpression of the MDM2 gene product can lead to excessive inactivation of p53 thereby diminishing its tumor suppressor function. The inactivation of p53 is mediated by the E3 ubiquitin ligase activity of MDM2 which targets p53 for proteasomal degradation. MDM2 also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5 (2). Amplification of MDM2 is frequently observed in human sarcomas and this is consistent with the hypothesis that MDM2 binds to p53 which then leads to escape from p53-regulated growth control. MDM2 Protein is ideal for investigators involved in Sigaling Proteins, Cell Cycle Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cell Cycle, and Cellular Stress research.
Catalog Number:
(75794-164)
Supplier:
Prosci
Description:
NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappaB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.
Catalog Number:
(TCB0586-25G)
Supplier:
TCI America
Description:
CAS Number: 776-74-9
MDL Number: MFCD00000134 Molecular Formula: C13H11Br Molecular Weight: 247.14 Purity/Analysis Method: >97.0% (GC,T) Form: Crystal Boiling point (°C): 193 Melting point (°C): 39 Flash Point (°C): 112 Storage Temperature: 0-10°C
Supplier:
TCI America
Description:
CAS Number: 14484-64-1
MDL Number: MFCD00067269 Molecular Formula: C3H7NS2 Molecular Weight: 416.47 Purity/Analysis Method: >97.0% (T) Form: Crystal
Supplier:
IBI Scientific
Description:
Select-D Columns are ideal for desalting and removing unincorporated radiolabeled deoxynucleotide triphosphates from end labels, fill in, nick-translation, or random primed DNA labeling reactions
Catalog Number:
(95034-198)
Supplier:
Spectrum Chemicals
Description:
Magnesium Citrate, Anhydrous, USP is often used as a saline laxative to clean stool from the intestines before surgery or certain bowel procedures. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Supplier:
Biotium
Description:
AccuBlue™ and AccuClear™ dsDNA quantitation assays provide sensitive, accurate and easy-to-use dsDNA quantitation assays for fluorescent microplate readers in 96-well or 384-well formats.
Catalog Number:
(76081-702)
Supplier:
Lucigen
Description:
Save by purchasing bulk quantities of the MasterPure™ buffers and reagents
Catalog Number:
(AA45572-06)
Catalog Number:
(AA88280-14)
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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