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Vanadium(III)+bromide
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Vanadium(III)+bromide
Catalog Number:
(10357-822)
Supplier:
Bioss
Description:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
Supplier:
BeanTown Chemical
Description:
CAS: 10108-64-2; EC No: 233-296-7; MDL No: MFCD00010916; RTECS: EV0175000
UN No: UN2570; Haz Class: 6.1; Packing Group: III
Powder; Molecular Formula: CdCl2; MW: 183.32
Melting Point: 568°
Hygroscopic
Catalog Number:
(103286-792)
Supplier:
Novus Biologicals
Description:
The SCN3A Antibody from Novus Biologicals is a rabbit polyclonal antibody to SCN3A. This antibody reacts with human. The SCN3A Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.
Supplier:
Anaspec Inc
Description:
Matrix metalloproteinases (MMP’s) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-1 (collagenase-1) is involved in tumor development and metastasis and rheumatoid arthritis. It is proposed as a therapeutic target for these diseases. MMP-1 digests a broad range of substrates, including α-1 antitrypsin, myelin basic protein, collagen I, II, III, VII, VIII, casein, gelatin, and others
Supplier:
BeanTown Chemical
Description:
CAS: 3430-14-6; MDL No: MFCD00833389
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Solid; Molecular Formula: C6H8N2 ; MW: 108.14
Melting Point: 95-99°
Supplier:
BeanTown Chemical
Description:
CAS: 3164-85-0; EC No: 221-625-7; MDL No: MFCD00045896
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CH3(CH2)3CH(CH2CH3)COOK; Molecular Formula: C8H15KO2; MW: 182.30
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 629-08-3; EC No: 211-071-4; MDL No: MFCD00039503
UN No: UN1992; Haz Class: 3 (6.1); Packing Group: III
Liquid; Linear Formula: CH3(CH2)5CN; Molecular Formula: C7H13N; MW: 111.19
Boiling Point: 186-187°; Flash point: 58°C (136°F)
Density (g/mL): 0.81
Catalog Number:
(10329-128)
Supplier:
Bioss
Description:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
Catalog Number:
(103225-558)
Supplier:
Novus Biologicals
Description:
Semaphorin 3F Antibody, Polyclonal, Host: Goat, Species reactivity: Human, Mouse, Isotype: IgG, Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Semaphorin 3F, Synonym: SEMA-IV, SEMAK, semaphorin III/F, Application: WB, Size: 50UG
Supplier:
BeanTown Chemical
Description:
CAS: 41851-59-6; MDL No: MFCD00671660
UN No: UN2735; Haz Class: 8; Packing Group: III
Liquid; Molecular Formula: C9H13NO; MW: 151.21
Density (g/mL): 1.024; Refractive Index: 1.533; Optical Rotation: [α]20/D +32±2°, neat
Air Sensitive
Catalog Number:
(10108-002)
Supplier:
Prosci
Description:
SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006).
Catalog Number:
(76805-890)
Supplier:
AMBEED, INC
Description:
(5-Bromopentyl)benzene, Purity: 95%, CAS Number: 14469-83-1, Appearance: Colorless to Yellow Liquid, Storage: Inert atmosphere, Room Temperature, Size: 250MG
Supplier:
BeanTown Chemical
Description:
CAS: 111-30-8; EC No: 203-856-5; MDL No: MFCD00007025; RTECS: MA2450000
UN No: UN2922; Haz Class: 8 (6.1); Packing Group: III
Liquid; Linear Formula: OHC(CH2)3CHO; Molecular Formula: C5H8O2; MW: 100.12
Density (g/mL): 1.106
Supplier:
BeanTown Chemical
Description:
CAS: 12208-13-8; EC No: 235-387-7; MDL No: MFCD00150439
UN No: UN1549; Haz Class: 6.1; Packing Group: III
Powder; Linear Formula: KSb(OH)6; MW: 262.90
Supplier:
BeanTown Chemical
Description:
CAS: 1575-37-7; MDL No: MFCD02660622
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Solid; Molecular Formula: C6H7BrN2; MW: 187.04
Melting Point: 65-69°
Catalog Number:
(103230-154)
Supplier:
Novus Biologicals
Description:
SALM4/LRFN3, Polyclonal Antibody, Host: Goat, Species: Human, Isotype: IgG, Immunogen: Mouse myeloma cell line NS0-derived recombinant human SALM4/LRFN3, Synonyms: leucine rich repeat and fibronectin type III domain containing 3, Application: WB, Size: 100UG
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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