cis-3,4-Dihydroxypyrrolidine+hydrochloride
Supplier:
AMBEED, INC
Description:
Isobutylamine hydrochloride 98%
Supplier:
AMBEED, INC
Description:
O-Methylhydroxylamine hydrochloride 98%
Catalog Number:
(76820-526)
Supplier:
AMBEED, INC
Description:
N-(3-Aminophenyl)acetamide hydrochloride, Purity: 95+%, CAS Number: 621-35-2, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 5G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 054490-500MG , MDL Number: MFCD14584786
Supplier:
Matrix Scientific
Description:
(R)-Ethyl-2-amino-3-hydroxypropanoate hydrochloride 95
Catalog Number:
(100266-130)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 10mg Fumarine HYDROChloride 389.83 Room temperature.
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Supplier:
AMBEED, INC
Description:
Ozagrel hydrochloride hydrate 97%
Supplier:
Matrix Scientific
Description:
Thiomorpholine-1-Oxide Hydrochloride, MF=C4H10Clnos MW=155.65 CAS: 76176-87-9 1G
Catalog Number:
(10801-424)
Supplier:
Rockland Immunochemical
Description:
FKBP1A is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and Rapamycin. FKBP1A interacts with various type I receptors, including the TGF-beta type I receptor and competitive binding assays show that the type I receptor may be a natural ligand for FKBP1A (1). FKBP1A-deficient mice have normal skeletal muscle but show severe dilated cardiomyopathy and ventricular septal defects that mimick a human congenital heart disorder (2). FKBP1A Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, AKT/PKB Pathway, Cardiovascular Disease, Inflammation, Neurobiology, and NfkB Pathway research.
Supplier:
AMBEED, INC
Description:
1-(Methylsulfonyl)piperazine hydrochloride, Purity: 97%, CAS Number: 161357-89-7, Appearance: White to Yellow Solid, Storage: Sealed in dry, Room Temperature, Size: 5G
Supplier:
AMBEED, INC
Description:
6-Chloronicotinimidamide hydrochloride, Purity: 95%, CAS number: 201937-23-7, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 250MG
Supplier:
Thermo Scientific Chemicals
Description:
Methyl 3-oxo-3, 4-dihydro-2H-1, 4-benzothiazine-6-carboxylate, Purity: 97%, CAS Number: 188614-01-9, Molecular Formula: C10H9NO3S, Synonym: 3-Oxo-3, 4-dihydro-2H-1, 4-benzothiazine-6-carboxylic acid methyl ester, 5G
Catalog Number:
(TCI0092-25G)
Supplier:
TCI America
Description:
CAS Number: 102-36-3
MDL Number: MFCD00002017 Molecular Formula: C7H3Cl2NO Molecular Weight: 188.01 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Boiling point (°C): 120 Melting point (°C): 40 Flash Point (°C): 123 Storage Temperature: 0-10°C
Catalog Number:
(TCD3419-5G)
Supplier:
TCI America
Description:
CAS Number: 38464-04-9
MDL Number: MFCD00040785 Molecular Formula: C12H16O4 Molecular Weight: 224.26 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 81
Supplier:
AMBEED, INC
Description:
2-Chloroacetimidamide hydrochloride, Purity: 97%, CAS Number: 10300-69-3, Appearance: Form: solid, Storage: Inert atmosphere, Room Temperature, Size: 1g
Catalog Number:
(10303-834)
Supplier:
Bioss
Description:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
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