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2-(Benzyloxy)-5-nitrobenzenecarboxylic+acid
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2-(Benzyloxy)-5-nitrobenzenecarboxylic+acid
Catalog Number:
(IC10088805)
Supplier:
MP Biomedicals
Description:
p-Nitrophenyl Acetate used with iodoacetic acid for reductive cleavage of methionine-containing peptides. It is also used as a substrate that has been used in assays for esterase and lipase activity. Inorganic complexes have been evaluated for their methanolysis or hydrolysis activity using p-nitrophenyl acetate.
Catalog Number:
(AA77137-14)
Supplier:
Adipogen
Description:
Tight-binding, reversible, highly selective inhibitor of acid proteases (aspartyl peptidases), like pepsin, gastricsin, cathepsin E and D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Does not inhibit thiol proteases, neutral proteases or serine proteases. Widely used as a research tool in studies of protease mechanisms and biological functions. Solubilized gamma-secretase and retroviral protease inhibitor. Shows antibacterial, antifungal and antiparasitic activity. Suppresses p53-dependent apoptosis in lymphoid cells as well as TNFalpha-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Supplier:
Thermo Scientific Chemicals
Description:
As a flux in galvanizing steel sheet, in batteries, to clean soldering irons, analytical lab reagent, in washing powders, electroplating, lustering cotton
Supplier:
Adipogen
Description:
Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion
Supplier:
Adipogen
Description:
Verapamil hydrochloride is an alpha-adrenergic receptor (alpha-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein). Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models. Verapamil helps treat diabetes by limiting TXNIP expression.
Supplier:
Adipogen
Description:
Selective inhibitor of 5-lipoxygenase. Apoptosis and cell cycle arrest inducer. Anticancer compound. Inhibits ERK1/2, JNK, and NF-kappaB activation and expression of Raf-1 and Ras. Anti-proliferative compound. Anti-inflammatory and immunosuppressive. Anti-apoptotic compound in hepatocytes. Antioxidant. Antidiabetic. Enhances hepatic and plasma glucose metabolism and increases insulin secretion in type 2 diabetic mice. Inhibits angiogenesis by blocking STAT3 and VEGF expression. Neuroprotective. PI3K Class I, MKK3/6 and MKK4 inhibitor. Shown to inhibit osteoporosis dually through transcriptional suppression and actin rearrangement.
Catalog Number:
(IC10262383)
Supplier:
MP Biomedicals
Description:
L-Phenylalanine is one of the 20 amino acids. It is an essential amino acid. It contains an aromatic side chain, which contributes to ultraviolet absorbance and fluorescence properties.
Supplier:
MP Biomedicals
Description:
Menadione belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione has demonstrated cytotoxic activity against a variety of cell culture lines and can induce apoptosis of cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.
Catalog Number:
(IC15727780)
Supplier:
MP Biomedicals
Description:
Guaiacol is a phenolic natural product first isolated from Guaiac resin, as well as the oxidation of lignin. It is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. Guaiacol is able to inhibit prostaglandin biosynthesis like a classic NSAID, but it does not induce gastric damage.
Catalog Number:
(102988-362)
Supplier:
Adipogen
Description:
Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has low nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. The binding affinity constant to PPARgamma is 12 times lower than Amorfrutin A . Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Antimicrobial agent.
Catalog Number:
(76177-666)
Supplier:
MP Biomedicals
Description:
Storage: Store at Room Temperature (15-30 °C)
Benzyl alcohol (BnOH) is a monoaromatic primary alcohol widely used as a solvent and an intermediate in cosmetic formulations, pharmaceutical and flavor/fragrance industries. It shows bacteriostatic property. Commercial method for its synthesis is by the alkaline hydrolysis of benzyl chloride. Conformational studies by ab initio calculations shows gauche cis conformation around the alcoholic group. Benzyl alcohol may be used for the benzylation of toluene.
Supplier:
MP Biomedicals
Description:
Soluble in water (50 mg/l- clear, colorless to slight yellowish solution) or methanol; less soluble in ethanol; practically insoluble in ether and ethyl acetate.
Supplier:
Adipogen
Description:
Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic.
Catalog Number:
(102988-598)
Supplier:
Adipogen
Description:
Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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