You Searched For: OPTEM

Catalog Number: (103264-944)

Supplier: Southern Biotechnology

Description: Rabbit F(ab')2 Anti-Goat IgG(H+L)-FITC antibody with minimal reactivity to human serum proteins for use in ELISA, flow cytometry, and western blotting assays.

Catalog Number: (103265-000)

Supplier: Southern Biotechnology

Description: Alexa Fluor 647 Anti-Goat IgG Fc antibody for use in western blotting, immunohistochemistry, and other fluorescent assays.

Catalog Number: (103265-022)

Supplier: Southern Biotechnology

Description: Rabbit Anti-Mouse IgG(H+L)-PE antibody with minimal reactivity to human proteins for use in flow cytometry assays.

Catalog Number: (103265-194)

Supplier: Southern Biotechnology

Description: Alexa Fluor 488 Anti-Human IgG2 Fc antibody for use in flow cytometry, immunohistochemistry, and western blotting assays.

Catalog Number: (103265-066)

Supplier: Southern Biotechnology

Description: Donkey Anti-Mouse IgG(H+L)-Alexa Fluor 647 antibody with minimal reactivity to human, goat, sheep, bovine, rabbit, chicken, horse, and guinea pig serum proteins for use in immunocytochemistry assays.

Catalog Number: (103265-060)

Supplier: Southern Biotechnology

Description: Donkey Anti-Mouse IgG(H+L)-HRP antibody with minimal reactivity to human, goat, sheep, bovine, rabbit, chicken, horse, and guinea pig serum proteins for use in ELISA and immunocytochemistry assays.

Catalog Number: (103265-170)

Supplier: Southern Biotechnology

Description: Alexa Fluor 488 Anti-Human IgG Fc antibody for use in flow cytometry and western blotting assays.

Catalog Number: (103265-042)

Supplier: Southern Biotechnology

Description: Purified Donkey F(ab')2 Anti-Mouse IgG(H+L) antibody for use in ELISA assays.

Catalog Number: (103265-090)

Supplier: Southern Biotechnology

Description: Purified Donkey F(ab')2 Anti-Rat IgG(H+L) antibody with minimal reactivity to mouse serum proteins for use in ELISA assays.

Catalog Number: (103265-218)

Supplier: Southern Biotechnology

Description: Alexa Fluor 647 Anti-Human IgG4 pFc' antibody for use in flow cytometry, immunohistochemistry, and western blotting assays.

Catalog Number: (103265-254)

Supplier: Southern Biotechnology

Description: CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin α4 chain. CD49d associates noncovalently with CD29, the integrin β1 subunit, to form the α4β1 very late antigen-4 (VLA-4) heterodimer. Integrin α4 can also associate with integrin β7 to form the α4β7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The α4β7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin α4β7 also binds to fibronectin and VCAM-1.

Catalog Number: (103265-290)

Supplier: Southern Biotechnology

Description: CD8 is a 33 kDa transmembrane glycoprotein expressed as either a CD8αα homodimer or CD8αβ heterodimer. It is expressed on the “cytotoxic/suppressor” subpopulation of peripheral T cells. CD8 functions primarily as a coreceptor with MHC class I-restricted TCR’s in antigen recognition.

Catalog Number: (103265-392)

Supplier: Southern Biotechnology

Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation.

Catalog Number: (103265-372)

Supplier: Southern Biotechnology

Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor α chain (IL-2Rα). CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor β chain) and CD132 (common γ chain) to form the high affinity IL-2 receptor. CD25 plays a role in lymphocyte differentiating and activation/proliferation. CD25 is expressed on activated B cells, monocytes/macrophages, and T cells.

Catalog Number: (103259-674)

Supplier: Southern Biotechnology

Description: Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Catalog Number: (103259-688)

Supplier: Southern Biotechnology

Description: The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-8 is a cytosolic protease that is capable of processing/activating all known caspases, indicating its presence early in the apoptotic cascade. It mediates cell death induction by receptors of the tumor necrosis factor (TNF) and nerve growth factor (NGF) family to eliminate injured cells and maintain leukocyte homeostasis. Moreover, studies have suggested it regulates Fas-induced cytotoxicity and may have a non-apoptotic role in macrophage differentiation. The SB125a monoclonal antibody detects a band at ~55kD corresponding to the full length form of caspase-8.