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Catalog Number: (10065-176)

Supplier: Diagnostic Biosystems

Description: The Picro-Sirius Red Stain Kit (For Collagen) is intended for use in the histological visualization of collagen I and III fibers in addition to muscle in tissue sections.

Supplier: Diagnostic Biosystems

Description: The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

Supplier: Diagnostic Biosystems

Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human factor VIII related antigen. It stains endothelial cells and megakaryocytes in various human tissues. This antibody does not cross-react with any other cell types.

Catalog Number: (76634-354)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a sialoglycoprotein of 27 to 32 kDa known as CD99 or MIC2 gene product. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes and granulosa cells of the ovary, sertoli cells of testis, pancreatic islet cells and some endothelial cells. Mature granulocytes express very little or no CD99.

Catalog Number: (76634-378)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 220 kDa protein. CD15 plays a role in mediating phagocytosis, bactericidal activity and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is also expressed in Reed-Sternberg cells and some epithelial cells. CD15 is very useful in the identification of Hodgkin disease.

Supplier: Diagnostic Biosystems

Description: Wilms tumor-1 (WT-1) is a gene involved in the induction of Wilms tumor, a pediatric renal malignancy. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma.

Catalog Number: (95025-204)

Supplier: Diagnostic Biosystems

Description: This kit is designed to label specific primary antibodies immunohistochemically on tissue sections. The immunohistochemical protocol defined in this brochure is just a guideline. Depending upon tissue fixation conditions, the primary antibody employed, and the user’s experience, we encourage individual laboratory to optimize its own protocol. These reagents were tested and quality controlled using tissue sections, however, they can also be optimized for cell smears and cytospin preparations. Sufficient reagents are provided to run 50 to 100 tests.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes cytokeratin polypeptides ranging from 40 to 58 kDa, corresponding to cytokeratins 5, 6, 8,17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia, like epidermis, mammary gland ducts and tracheal epithelium.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a glycoprotein of 110 kDa, expressed as intracytoplasmic molecule. It stains macrophages in a wide variety of tissues. Myeloid precursor cells and peripheral granulocytes are negative. The PG-M1 differs from EMB11 (CD68) because of its non-reactivity with granulocytes and their precursor cells.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to α and γ specific actin isomers from skeletal, cardiac and smooth muscle but does not recognize β and nonsmooth muscle γ actin isomers.

Supplier: Diagnostic Biosystems

Description: This antibody stains C cells of thyroid.

Catalog Number: (76634-528)

Supplier: Diagnostic Biosystems

Description: Myeloperoxidase metabolizes most of the hydrogen peroxide generated by activated phagocytes. This antibody stains strongly with the cytoplasm of myeloid cells. The antibody detects myeloperoxidase found in myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been localized to chromosome 17.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with two glycoproteins of 34 and 49 kDa present on the epithelial cells. It stains with simple epithelia and basal layers of stratified non-keratinized squamous epithelium.

Supplier: Diagnostic Biosystems

Description: This antibody is specific for α-skeletal muscle actinin and α-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements.

Catalog Number: (76634-510)

Supplier: Diagnostic Biosystems

Description: O(6)-methylguanine-DNA-methyltransferase (MGMT) is a 22 kDa human DNA repair protein that removes O(6)-alkylguanine DNA adducts. MGMT acts as a suicide acceptor protein repairing the DNA by accepting alkyl groups and consequently inactivating itself. This antibody stains all mantle zone lymphocytes and 50% of germinal center lymphocytes. Basaloid epithelial cells of tonsil squamous mucosa are also stained positive with this antibody.