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Catalog Number:
(76634-886)
Supplier:
Diagnostic Biosystems
Description:
ROS1 rearrangements occur infrequently in lung ACA, however given the frequency of lung cancer in the population, ROS1-rearranged tumors represent a significant number of cancer patients. ROS1 gene rearrangements are reported in 1 to 2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS IHC can be readily incorporated into the diagnostic surgical pathology workup of lung adenocarcinoma, with results confirmed by FISH as needed.
Supplier:
Diagnostic Biosystems
Description:
Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 55 kDa protein known as platelet-derived endothelial growth factor (PD-ECGF), or thymidine phosphorylase (TP). High levels of TP/PD-ECGF are observed in cancer patients. High intracellular levels of TP/PD-ECGF are associated with increased sensitivity to fluoropyrimidine chemotherapeutic agents.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of P53 protein, known to reside between amino acids 35 to 45. This antibody can be demonstrated in 22 to 76% of the colon, stomach, bladder, breast, lung and testes cancers.
Catalog Number:
(76634-880)
Supplier:
Diagnostic Biosystems
Description:
p63 is a homolog of the tumor suppressor p53, it is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90% . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with HSV type I specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.
Supplier:
Diagnostic Biosystems
Description:
PRAME (Preferentially expressed Antigen in Melanoma) is a tumorassociated antigen and is a member of the family of cancer testis antigens (CTA). PRAME is expressed in malignant cells, including leukaemias, Hodgkin's lymphoma, breast cancer, and primary and metastatic melanomas. PRAME has low or no expression in normal tissues except for in testis, ovary, placenta, adrenals and endometrium.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 180 kDa protein, known as Flk-1, KDR or vascular endothelial growth factor receptor 2 (VEGFR2). Flk-1 is a cell membrane receptor kinase. Flk-1 is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the whole <i>H. pylori</i>. The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. <i>H. pylori</i> is known to cause peptic ulcer and chronic gastritis in humans.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 95-100 kDa protein. This antibody recognizes amyloid precursor proteins APP695, APP751 and APP770. Amyloid precursor protein and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 33-36 kDa protein known as ERCC1 (excision repair cross complementing) polypeptide. ERCC1 is required for nucleotide excision repair of damaged DNA and is homologous to RAD10. In mammalian cells, XPG cleaves 3’ of the DNA lesion while ERCC1-XPF complex makes the 5’ incision.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues, IgM containing plasma cells stain strongly but immune complexes are usually undetectable.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 33 kDa polypeptide present on the majority of B cells in peripheral blood and lymphoid tissue. No reactivity with other hematopoietic cells has been observed.
Supplier:
Diagnostic Biosystems
Description:
The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to human CD10 antigen of 100 kDa, also known as common acute lymphocytic leukemia antigen (CALLA). CD10 antigen has been identified on the surface of early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.
Supplier:
Diagnostic Biosystems
Description:
The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin and substance P. CD10 is expressed by a number of hematopoietic cells such as immature T and B cells, B cells of the germinal centers of lymphoid follicles and granulocytes. It also reacts with a variety of non-hematopoietic cells, including epithelial cells in GI tract and kidney tubular. In liver, the bile canaliculi shows a moderate to strong staining. CD10 has been used for the identification and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis. It is also known to be a marker of endometrial stromal cells. It is helpful in differentiating endometrial stromal sarcoma (ESS) from uterine cellular leiomyoma (UCL) and uterine leiomyosarcoma (ULS).
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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