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Supplier: Adipogen

Description: Potent antileukemia and antimyeloma compound. Apoptosis inducer. Delays tumor growth. Cyclin D2 promoter transactivation inhibitor. Inhibitor of pan-Class I PI3K isoforms.

Catalog Number: (102516-222)

Supplier: Adipogen

Description: Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

Supplier: Adipogen

Description: Cell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.

Supplier: Adipogen

Description: Aminopolycarboxylic acid. A powerful, readily chelant. Complexing agent, exhibiting superior biological degradation (environmentally friendly) compared to EDTA. Used in cosmetic formulations, as effective anti-oxidant and water hardness control, to reduce radical generation, as effective peroxide stabiliser, as preservative potentiator improving piocide efficacy and excellent transition metal chelator.

Supplier: Adipogen

Description: Synthetic. Originally isolated from the marine sponge <i>Angelas mauritianus</i>. Immunostimulant. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Protects against LPS-induced shock. Potent antitumor compound.

Supplier: Adipogen

Description: Chemopreventive probe. Apoptosis inducer. Potent anti-tumor compound. Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-kappaB activation. Antinociceptive. Probe to study chemokine receptors functioning. Potential therapeutic agent for osteoporosis and cancer-associated bone loss. Anti diabetic nephropathy

Catalog Number: (102513-474)

Supplier: Adipogen

Description: Nucleoside antibiotic. Antitumor compound. Xanthosine monophosphate (XMP) aminase inhibitor. RNA synthesis inhibitor. Specific GMP synthase inhibitor. Reduces intracellular GTP levels.

Supplier: Adipogen

Description: Rebeccamycin is a weak topoisomerase I (Topo I) inhibitor.

Supplier: Adipogen

Description: Mycotoxin. Cytotoxic. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.

Catalog Number: (102516-124)

Supplier: Adipogen

Description: Sonic hedgehog (Shh) signaling modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein.

Supplier: Adipogen

Description: Necroptosis inhibitor. Does not inhibit RIP1 kinase.

Supplier: Adipogen

Description: Very potent PARP-1 inhibitor.

Supplier: Adipogen

Description: Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor.

Supplier: Adipogen

Description: A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd <lt/> 7 nM). Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki <lt/> 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki <lt/> 50 µM). Inhibits tumor growth. Increases vasoconstriction to noradrenaline. Improves contractile function. Improves stroke outcome and decreases glutamate release. Anti-inflammatory. Review.

Catalog Number: (102513-494)

Supplier: Adipogen

Description: Cladospirone bisepoxide is a germination inhibitor.

Supplier: Adipogen

Description: Antibiotic