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ACS Scientific Inc
Catalog Number:
(76334-036)
Supplier:
Biosensis
Description:
Calretinin antibody, Host: Rabbit, Reactivity: human, Immunogen: Full-length recombinant human protein, Synonyms: CR; 29 kDa calbindin, Purity: Whole serum, Form: Lyophilised, without preservatives, Applications: W
Supplier:
Biosensis
Description:
The Biosensis proNGF RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of full-length proNGF protein in less than 4 hours in human serum, heparin-plasma, cell supernatants and lysates only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application.
Supplier:
Biosensis
Description:
The Biosensis NGFR/p75ECD RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of mouse p75ECD in less than 4 hours n cell culture supernatants and urine only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application.
Catalog Number:
(10782-116)
Supplier:
Biosensis
Description:
High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).
Catalog Number:
(10781-936)
Supplier:
Biosensis
Description:
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) and upon binding to the receptor it induces the release of growth hormone from the pituitary. This ligand has an appetite-stimulating effect and is involved in growth regulation (Ref: SWISSPROT).
Catalog Number:
(10781-918)
Supplier:
Biosensis
Description:
Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP is an 'intrinsically unstructured' protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system. A detailed immunochemical examination of monoclonal and polyclonal antibody responses to MBP and its peptides has revealed the existence of as many as 27 antigenic determinants, many of them conformational. Topological mapping of the potential antigenic determinants onto a model of MBP secondary structure places these determinants within 11 separate regions of the molecule, including those portions that have been found to be encephalitogenic. The message for myelin basic protein is selectively translocated to the ends of the cell processes. Immunization with myelin-associated antigens including MBP significantly promotes recovery after spinal cord contusion injury in the rat model. FUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Myelin membrane; peripheral membrane protein; cytoplasmic side. Cytoplasmic side of myelin. TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.
Catalog Number:
(10782-020)
Supplier:
Biosensis
Description:
Neuropeptide VF is the precursor of neuropeptides NPSF (RFRP-1), RFRP-2 and RFRP-3 (NPVF). RFRP-3 is reported to inhibit forskolin-induced production of cAMP. RFRP-3 has also been shown to block morphine-induced analgesia.
Catalog Number:
(10781-980)
Supplier:
Biosensis
Description:
Transforming growth factor beta-1 (TGFB1) is a multi-functional cytokine with roles in proliferation, differentiation and other functions in many cell types. The secreted TGFB1 protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide (Ref: SWISS-Prot).
Catalog Number:
(10782-082)
Supplier:
Biosensis
Description:
TAR DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing (ref: SWISSPROT).
Catalog Number:
(76459-464)
Supplier:
Biosensis
Description:
Fluoro-Jade C stains all degenerating neurons regardless of specific insult or mechanism of cell death. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols.
Catalog Number:
(76459-468)
Supplier:
Biosensis
Description:
GFP Polyclonal Antibody, Host: Rabbit, Purity: Affinity purified, Antigen: Recombinant AcGFP purified from E. Coli, Molecular Weight: approx 27 kDa, Form: Lyophilized from a solution containing PBS, pH 7.2-7.6, Application: Immunocytochemistry, and Western Blot, Size: 100ug
Catalog Number:
(76334-048)
Supplier:
Biosensis
Description:
IBA1 antibody, Host: Rabbit, Reacts with human, rat, mouse, Purity: whole serum, Antigen: C-terminal peptide of human IBA1 protein coupled to KLH, Applications: WB, ICC, Storage: Store lyophilised antibody at 2-8C,
Catalog Number:
(76333-990)
Supplier:
Biosensis
Description:
Actin Monoclonal antibody, Clone: 5J11, Host: mouse, Reactivity: Human, rat, Isotype: IgG1, Immunogen: Actin prepared from bovine brain, Applications: WB, ICC, FLOW, Form: Lyophilized from PBS. Contains 5% trehalos
Catalog Number:
(76334-004)
Supplier:
Biosensis
Description:
Heat Shock Protein 27 Monoclonal antibody, Clone: 6H11, Host: mouse, Reactivity: Human, Isotype: IgG1, Specificity: reacts with a 27 kDa band on a crude extract from HeLa cells, Applications: WB, ICC, Flow, Form:
Catalog Number:
(76333-986)
Supplier:
Biosensis
Description:
Neurotrophin Antibody Kit (Trial Size) contains 500 ug each of popular sheep antibodies raised against BDNF, NGF, NT3 and NT4/5, and a negative control sheep IgG, to investigate neurotrophin protein expression and
Catalog Number:
(10782-444)
Supplier:
Biosensis
Description:
The Human influenza hemagglutin (HA) tag corresponds to a region (98-106 amino acids) from the HA molecule.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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