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CAYMAN CHEMICAL COMPANY, INC.
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CAYMAN CHEMICAL COMPANY, INC.
Supplier:
Cayman Chemical Company
Description:
PS-1145, Purity >/=98%, CAS 431898-65-6, MF: C17H11ClN4O, MW: 322.8, Synonyms: IKK Inhibitor X, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide, Formulation: A crystalline solid, Size: 500ug
Catalog Number:
(76544-308)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76543-964)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Supplier:
Cayman Chemical Company
Description:
For the measurement of 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanosine.
Catalog Number:
(76543-968)
Supplier:
Cayman Chemical Company
Description:
An internal standard for the quantification of XLR11 N-<wbr/>(4-<wbr/>hydroxypentyl) metabolite by GC-<wbr/> or LC-<wbr/>MS
Catalog Number:
(76292-904)
Supplier:
Cayman Chemical Company
Description:
IFR3 (S386A, S396A mutant; human recombinant) contains amino acids corresponding to human IRF3 (Item No. 22811) with alanine substituted for serine at positions 386 and 396. Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation through serine/threonine phosphorylation by TBK1 (Item No. 22817) or IKKε (IKBKE) kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREB binding protein (CREBBP)/p300. The complex formed by this association, known as DRAF1, activates transcription of interferon α (IFN-α) and IFN-β as well as other IFN-induced genes, which play a critical role in the type 1 IFN-dependent immune response. Various serine residues have been implicated in IRF3 activation, including S386 and S396. TBK1 and IKKε phosphorylation of IRF3 is decreased when serine is replaced with alanine at positions 396, 398, 402, and 405 and with threonine at position 404. Phosphorylation of S386 is essential for IRF3 oligomerization and binding to p300, and phosphorylation of S396, T390, and either S385 or S386 occurs following Sendai viral infection in HEK293 cells.
Catalog Number:
(76544-578)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Supplier:
Cayman Chemical Company
Description:
For the rapid measurement of 8-iso PGF<sub>2α</sub> from biological samples.
Catalog Number:
(76544-730)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-012)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-148)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-258)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-282)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-370)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-140)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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