Downstream purification for mAbs

Major processes including affinity, ion exchange, HIC and size exclusion require chromatography resins and process buffers. These products help ensure that the quality of the target mAb is maintained through each step — bioreactor harvest to the bulk drug substance.

In the manufacturing of mAbs, Avantor J.T.Baker® brand BAKERBOND™ chromatography resins are proven to reduce total purification steps while improving purity and yield. These resins have been used successfully in commercial and clinical manufacturing of protein therapeutics and feature a unique multi-mode chemistry that works to increase yield by improving the efficiency of your purification process and enhancing selectivity by removing closely related impurities.

J.T.Baker® brand and VWR Bioprocessing buffers for column equilibration and protein elution — as well as buffers used to support protein solutions for various process hold steps — are also offered to complement our chromatography resins. Choose from a variety of formats and packaging configurations to best address your needs in process development, scale-up and commercial manufacturing.