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5-Bromo-6-(trifluoromethyl)pyrimidin-4(1H)-one
Catalog Number:
(72060-064)
Supplier:
Epredia
Description:
Epredia™ denatured Ethyl Alcohol is formulated to rigid specifications; providing laboratories with a high-quality product. Packaged in high-density polyethylene bottles featuring easy-to-pour design to reduce spills.
Catalog Number:
(AA11897-09)
Supplier:
Thermo Scientific Chemicals
Description:
Preparation of nonmetallic thiocyanates, analytical reagent, in photographic emulsions, as an organic intermediate
Catalog Number:
(IC15255405)
Supplier:
MP Biomedicals
Description:
Phenol Red Sodium Salt is used as a pH indicator, it is used widely in culture media to identify changes from neutral to acidic pH values.
Catalog Number:
(76002-378)
Supplier:
Enzo Life Sciences
Description:
Biosynthesis by platelet 12-lipoxygenase. Chemotactic and chemokinetic for PMNL2 and for vascular smooth muscle cells. Antiproliferative effect on smooth muscle cells. Second messenger in angiotensin induced aldosterone production. Induces endothelial cell retraction and tumor cell adhesion.
Supplier:
Adipogen
Description:
SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Supplier:
TCI America
Description:
CAS Number: 290835-85-7
MDL Number: MFCD02093760 Molecular Formula: C8H5Cl2FO Molecular Weight: 207.03 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 255 Specific Gravity (20/20): 1.40
Supplier:
Adipogen
Description:
Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective.
Catalog Number:
(80055-978)
Supplier:
MilliporeSigma
Description:
A natural dietary compound reported to have anticarcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID50=3.7µM). Inhibits Ca2+-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.
Supplier:
MP Biomedicals
Description:
2-Methylisothiazolone (MIT) are chemical compounds used as highly effective biocidal agents against fungal and bacterial species. They are widely used as a preservative in cosmetic industry, and as a pesticide, e.g. in paints and water tanks.
Catalog Number:
(IC800506)
Supplier:
MP Biomedicals
Description:
Pyronin Y is a cationic xanthene dye. A marker dye for acid buffer systems, indicating the migrating boundary during electrophoresis. Pyronin Y solutions are red in transmitted light, displaying a yellow flouresence in reflected light.
Catalog Number:
(102991-276)
Supplier:
Adipogen
Description:
CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.
Supplier:
Adipogen
Description:
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor (IC(50) values of 17.7, 32.6, 76.9 and 12942nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP, respectively. In binding assays, (+)-JQ1 binds competitive with acetyl lysine to BRD4 bromodomain 1 (Kd=50nM) and and BRD4 bromodomain 2 (Kd=90 nM). May be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. (+)-JQ1 exhibited strong dose- and time-dependent inhibition of BRDT, a bromodomain-containing protein highly enriched in testis. BRDT is involved in chromatin remodeling and is essential for healthy sperm development. (+)-JQ1 appears to block that function and causes a decrease in sperm viability, being examined as a potential male contraceptive. Inhibitor of inflammation and bone destruction.
Supplier:
Adipogen
Description:
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to <lt/>200nM.
Supplier:
Adipogen
Description:
Alcian blue 8GX is primarily used for demonstrating acid mucopolysaccharides, which it does quite selectively. In recent years there has been some difficulty obtaining the dye. Alcian Blue 8GX is also suitable for detection of glycoproteins on nitrocellulose and in PAGE gels.There are other dyes similar to alcian blue, although not necessarily belonging to the same class of dyes. Alcian green has gained some popularity, and alcian yellow has been suggested, especially in a method for demonstrating helicobacter. They are used for acid mucopolysaccharides in the same way as alcian blue. They have no particular advantage for demonstrating mucin. According to the Merck Index the groups marked X split off during staining.
Supplier:
MP Biomedicals
Description:
Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a cholesterol sequestering agent.
Supplier:
MP Biomedicals
Description:
Nile Red is an uncharged, hydrophobic, photostable molecule that strongly fluoresces bright red in hydrophobic environments. It is a fluorescent stain for intracellular lipid droplets.
Nile red can be used for the rapid determination of lipids by thin-layer chromatography or for staining whole tissue such as atherosclerotic blood vessels.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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