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2-(2-Methoxyphenoxy)benzoic+acid
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2-(2-Methoxyphenoxy)benzoic+acid
Supplier:
Adipogen
Description:
AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
Catalog Number:
(10069-576)
Supplier:
Prosci
Description:
Polyclonal, Host: Goat, Species Reactivity: Virus, Immunogen: Pool of purified virus (types 1-3), Tested Applications: Western blotting
Catalog Number:
(76835-234)
Supplier:
ANTIBODIES.COM LLC
Description:
Goat anti-chicken IgY Fc (FITC) secondary antibody for IHC, ICC and IF with samples derived from Chicken.
Catalog Number:
(89262-960)
Supplier:
Genetex
Description:
Rat monoclonal antibody [2A11] to Dectin-1
Catalog Number:
(89288-318)
Supplier:
Genetex
Description:
Rat monoclonal antibody [2A11] to Dectin-1
Catalog Number:
(89279-598)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [Bu12] to CD19
Catalog Number:
(89333-540)
Supplier:
Genetex
Description:
Rat monoclonal antibody [2F8] to SR-AI / MSR
Catalog Number:
(89262-982)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [2-176] to CD5
Catalog Number:
(89262-896)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [CC101] to Wc1
Catalog Number:
(89329-724)
Supplier:
Genetex
Description:
Clone: CRIS1 Conjugation: FITC Purity: n/a Species Reactivity: Human Tested Applications: FACS Pkg Size: 100 test
Catalog Number:
(89279-956)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [NKTA255] to LAIR1
Catalog Number:
(10725-932)
Supplier:
Abnova
Description:
Mouse monoclonal antibody raised against MS4A1.
Catalog Number:
(76961-584)
Supplier:
ANTIBODIES.COM LLC
Description:
Rat IgG2a [RTG2A1-1] (FITC) - Isotype Control for Flow Cytometry and Isotype Control.
Catalog Number:
(10676-778)
Supplier:
Abnova
Description:
Mouse monoclonal antibody raised against LTF.
Catalog Number:
(76954-930)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [JOVI.1] antibody to TCR C beta 1 (FITC) for Flow Cytometry with samples derived from Human.
Catalog Number:
(89274-990)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [CC-G33] to CD14
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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