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(4-Ethoxy-2-fluorophenyl)methanol
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(4-Ethoxy-2-fluorophenyl)methanol
Supplier:
Adipogen
Description:
Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion
Supplier:
Adipogen
Description:
Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport.
Catalog Number:
(80053-430)
Supplier:
MilliporeSigma
Description:
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t¹/₂ = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM).
Supplier:
Adipogen
Description:
Tremorgenic. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)). Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. Liver X receptor (LXRalpha and LXRbeta; NR1H3 and NR1H2) agonist in biochemical and in vitro cell-based assays. Anticonvulsant. Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis. Shown to protect neuronal cells against glutamate-induced cell death.
Catalog Number:
(102988-950)
Supplier:
Adipogen
Description:
Resorcylic acid lactone. Mycotoxin. Regulator of fungal morphogenesis. Mycoestrogen with anabolic and uterotrophic activity. Ecdysteroid antagonist. Gonadotropin inhibitor. Interleukin antagonist. Apoptosis inducer. Analytical standard in food industry.
Supplier:
Adipogen
Description:
Antibiotic
Supplier:
Adipogen
Description:
Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. D-lysine). Can also be used as building block.
Supplier:
Adipogen
Description:
Potent, specific and competitive inhibitor of type II 5alpha-reductase (enzyme which converts testosterone to the more potent 5alpha-dihydrotestosterone). Anticancer compound. Apoptosis modulator. Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications. Inhibit testosterone-induced type I procollagen and TGF-beta1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia. Drug for the treatment of male androgenetic alopecia. Potential role in neuropsychiatric disorders.
Catalog Number:
(102988-874)
Supplier:
Adipogen
Description:
Mycotoxin. Chelation agent with polyfunctional skeleton for development of biologically active compounds. Moderate antibacterial agent. Tyrosinase inhibitor. Inhibits catecholase activity of tyrosinase. Anti-melanogenic. Skin whitening agent. Antioxidant. Reactive oxygen species (ROS) scavenger. D-Amino acid oxidase (DAAO) inhibitor. Shown to inhibit NF-kB activation. Inducer of macrophage activation. Radioprotectant activity. Antileishmanial agent. Insecticidal. Antifungal chemosensitizer. Used in cosmetics and as food additive.
Supplier:
Adipogen
Description:
Antibiotic. Shows antiviral, antifungal and antitumor properties. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform. Inhibits RNA and DNA synthesis. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor. Apoptosis and necrosis inducer. Novel type of inhibitor against RNA guanylyltransferases. Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation.
Supplier:
BeanTown Chemical
Description:
CAS: 100243-39-8; MDL No: MFCD00192426
Liquid; Molecular Formula: C4H9NO; MW: 87.12
Flash point: 109°C (228°F)
Density (g/mL): 1.078; Refractive Index: 1.490; Optical Rotation: [α]20/D -6.5±1.5°, c = 3.5% in methanol
Air Sensitive, Hygroscopic
Supplier:
Adipogen
Description:
Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
Supplier:
Thermo Scientific Chemicals
Description:
Purity: 90%
Storage Temperature: -30°C to -10°C
Flash Point: <gt/>110°(230°F)
Physical Form: Powder
Boiling Point: 582°
Solubility: Soluble in methanol, ethanol, or acetone. Also soluble in dilute solutions of sodium bicarbonate or sodium acetate
Catalog Number:
(82022-380)
Supplier:
G-Biosciences
Description:
Bestatin.HCl is a competitive inhibitor of surface aminopeptidases, including aminopeptidase B (Ki=2nM), leucine aminopeptidase (Ki=20nM). Also inhibits aminopeptidases N; does not inhibit endoproteases. Solubility: Soluble up to 5 mg/ml in methanol or 1 mg/ml in 0,15 M NaCl.
Catalog Number:
(700012-802)
Supplier:
Spectrum Chemicals
Description:
Polyethyleneimine, 50 Percent (v/v) Aqueous Solution, or PEI, is soluble in hot water as well as in methanol, ethanol, chloroform and at low pH. It ability to modify the surface of cellulose fibres make it usable in many products such as adhesives, cosmetics, water treatment agents and detergents
Supplier:
Adipogen
Description:
A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Regulates lipolysis in insects. Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides. Shows biological effects on mammalian species. Neurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentiates GABAergic inhibition in rat. Was shown to stimulate and modulate neutrophil production. Antidiabetic and antiobesity. Could be used as a nutritional supplement for the prevention and treatment of obesity and obesity-associated disorders. May protect PC12 cells against CoCl(2)-induced cell injury by inhibiting ROS production and modulating components of the mitochondrial apoptosis pathway. Does not have potent anabolic properties, however, a muscle-specific increase is observed and genes are identified to provide an explanation for the muscle accretion. Potential fibrosis antagonist for renal proximal tubule cells. Acts through suppressing post-receptor signaling of TGF-beta1 and blocking the expression of Snail.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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