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Catalog Number:
(75930-262)
Supplier:
Rockland Immunochemical
Description:
Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth (1). Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3).
Catalog Number:
(75834-646)
Supplier:
Restek
Description:
These solutions are prepared from a single-source (one-refinery) product
Catalog Number:
(10822-216)
Supplier:
Shenandoah Biotechnology
Description:
The p28 subunit of interleukin 27 (IL-27), also known as interleukin 30 (IL-30), is a member of the interleukin 12 (IL-12) family of cytokines. p28 is a secreted polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naïve CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with cytokine-like factor 1 (CLF), that is secreted by dendritic cells, to regulate natural killer (NK) and T cell functions.
Supplier:
Enzo Life Sciences
Description:
Caspase-3 activator.
Catalog Number:
(76194-522)
Supplier:
Prosci
Description:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. It is required for normal immune responses. This antibody is specific to the epsilon chain of CD3.
Supplier:
Matrix Scientific
Description:
MF=C10H12Os MW=180.27 Cas=1200-13-1 MDL=MFCD00052713 1G
Catalog Number:
(75834-752)
Supplier:
Restek
Description:
This mix has two components: 3-Nitro-o-xylene (1,000 μg/ml) and 2,3,4,5-Tetrachlorophenol (2,000 μg/ml)
Catalog Number:
(103360-886)
Supplier:
Novus Biologicals
Description:
The PRMT6 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PRMT6. This antibody reacts with human, mouse. The PRMT6 Antibody has been validated for the following applications: Western Blot.
Supplier:
TCI America
Description:
CAS Number: 13170-62-2
MDL Number: MFCD00143578 Molecular Formula: C20H20N2 Molecular Weight: 288.39 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 127
Supplier:
Enzo Life Sciences
Description:
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.
Supplier:
Biolegend
Description:
PE anti-Histone H3 Phospho (Ser28) [HTA28]; Isotype: Rat IgG2a, κ; Reactivity: Human; Apps: ICFC; Size: 100 tests
Supplier:
Adipogen
Description:
Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.
Catalog Number:
(200014-080)
Catalog Number:
(SXS-430)
Supplier:
SPEX CERTIPREP LLC
Description:
Single-Component organic standards.
Catalog Number:
(101095-078)
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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