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1-(2,3-Difluoro-4-iodophenyl)ethanol
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1-(2,3-Difluoro-4-iodophenyl)ethanol
Supplier:
Adipogen
Description:
Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. AZD7762 is a specific inhibitor for the CHK1/2 kinases with IC(50) values less than 10. AZD7762 enhances radiation sensitivity and gemcitabine-mediated radiosensitization in pancreatic cancer cells and xenografts and thus is helpful in the treatments of potentially many cancers. In addition, AZD7762 is a chemosensitizer and with gemcitabine and radiation produced a significant delay in the growth of pancreatic tumor xenografts with tolerable toxicity. AZD7762 is being studied as an important link in improving both adjuvant therapy and the treatment of metastatic disease.
Supplier:
VWR International
Description:
These VWR® Plus Series stainless steel refrigerators feature a multi-functional design for laboratory use.
Supplier:
TCI America
Description:
CAS Number: 367-27-1
MDL Number: MFCD00009715 Molecular Formula: C6H4F2O Molecular Weight: 130.09 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 52 Flash Point (°C): 56 Freezing point (°C): 22
Supplier:
Adipogen
Description:
Steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides.
Catalog Number:
(IC19017080)
Supplier:
MP Biomedicals
Description:
Cyproheptadine is a Ca2+ channel blocker; 5-HT2 serotonin receptor antagonist; antihistamine, antipruritic. It is a migraine prophylactic.
Supplier:
BeanTown Chemical
Description:
CAS: 111-42-2; EC No: 203-868-0; MDL No: MFCD00002843; RTECS: KL2975000
Liquid/Low Melting Solid; Linear Formula: HN(CH2CH2OH)2; Molecular Formula: C4H11NO2; MW: 105.14
Melting Point: 28°; Boiling Point: 217°/150 mmHg; Flash point: 138°C (280°F)
Density (g/mL): 1.097; Refractive Index: 1.477
Hygroscopic
Supplier:
Adipogen
Description:
Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
Supplier:
Adipogen
Description:
Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. D-lysine). Can also be used as building block.
Catalog Number:
(57018-811)
Supplier:
VWR International
Description:
For platforms used with VWR* and VWR Signature* Orbital Shakers. Holds Erlenmeyer flasks. Spring holds flasks in place. Stainless steel construction with flat head screw for attachment. Capacity: 33x34cm-13, 45x45cm- 23, 61x61cm- 42, 61x91cm-68. Zinc plated music wire.
Supplier:
Adipogen
Description:
Oxysterole. Cholesterol oxidation metabolite. Induces cell death/apoptosis and shows antiproliferative activity against cancer cells, involving mitochondrial perturbation, oxidative stress and lysosomal destabilization. Its membrane organizing properties may have implications in Alzheimer’s disease. Increased levels correlate with risk of cardiovascular diseases including atherosclerosis. Shown to have proinflammatory activity.
Supplier:
Adipogen
Description:
Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor cell lines with nanomolar potency. Apoptosis inducer.
Supplier:
Adipogen
Description:
Anti-hypercholestrolemic compound. Anti-inflammatory and immune-modulating effects. Anticancer compound. Chemopreventive. Cytostatic. Cell growth inhibitor. Antimutagenic. Potent in vitro antagonist of FXR (farnesoid X receptor). DNA polymerase beta inhibitor. Potent antioxidant, hypoglycemic and thyroid inhibiting agent. Anti-osteoarthritic. Decreases the expression of matrix metalloproteinases. Neuroprotective. Is used as a precursor for synthetic progesterone and vitamin D3 and is an intermediate in the biosynthesis of androgens, estrogens and corticoids.
Supplier:
BeanTown Chemical
Description:
CAS: 206986-87-0; MDL No: MFCD00064138; RTECS: FZ9600000
Solid; Molecular Formula: C24H39NaO5·xH2O; MW: 430.55 (anhydrous)
Optical Rotation: [α]20/D +36±2°, c = 0.6% in ethanol (dry matter)
Hygroscopic
Catalog Number:
(10819-834)
Supplier:
VWR International
Description:
Includes an extra wire frame shelf made to fit VWR® Standard series laboratory refrigerators. (Includes SLV models).
Catalog Number:
(700003-464)
Supplier:
Spectrum Chemicals
Description:
2-Ethoxyethanol, Reagent is a clear and colorless liquid that is water miscible and also referred to as ethyl cellosolve, a widely used solvent. It is used to dissolve chemically diverse compounds such as oils, resins, waxes among others. Its reagent grade means this is the highest quality commercially available for this chemical and that the American Chemical Society has not officially set any specifications for this material.
Catalog Number:
(TCB1288-025G)
Supplier:
TCI America
Description:
CAS Number: 444-14-4
MDL Number: MFCD00009639 Molecular Formula: C6H4BrF2N Molecular Weight: 208.01 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 41 Flash Point (°C): 81
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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