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Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044556-5G , MDL Number: MFCD03001268
Supplier:
Adipogen
Description:
Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC(50) = 42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC(50) = 1 and 0.5µM) and Ba/F3-Tel-KDR and wt-Ba/F3 cells (IC(50) = 3.0 and 5.6µM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.).
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044952-1G , MDL Number: MFCD06659565
Supplier:
Matrix Scientific
Description:
2-(6-Methoxynaphthyl)trifluoromethyl ketone ≥97%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044955-500MG , MDL Number: MFCD06659567
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 049786-500MG , MDL Number: MFCD13560188
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045276-5G , MDL Number: MFCD05663800
Supplier:
AMBEED, INC
Description:
2,2,2-Trifluoro-1-(2-(methylamino)phenyl)ethanone, Purity: 98%, CAS Number: 202270-41-5, Appearance: Pale-yellow to Yellow-brown Liquid or Semi-solid or Solid, Storage: Keep in dark place, Inert atmosphere, 2-8C, Size: 100MG
Supplier:
AOB CHEM USA
Description:
2,2,2-Trifluoro-1-(3-(methoxymethyl)phenyl)ethanone ≥97%
Catalog Number:
(101818-360)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 024580-500MG , MDL Number: MFCD02681921
Supplier:
AMBEED, INC
Description:
1-(4-(5H-Tetrazol-5-yl)phenyl)ethanone, Purity: 97%, CAS Number: 552846-23-8, Appearance: White to off-white powder or crystals, Storage: Inert atmosphere, Room Temperature, Size: 250mg
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044982-1G , MDL Number: MFCD00244691
Supplier:
AMBEED, INC
Description:
1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone 98+%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044198-500MG , MDL Number: MFCD03001254
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 047608-1G , MDL Number: MFCD00173669
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045787-1G , MDL Number: MFCD06659605
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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