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\u03B1-Bromo-2-(trifluoromethoxy)toluene
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\u03B1-Bromo-2-(trifluoromethoxy)toluene
Catalog Number:
(10426-510)
Supplier:
Bioss
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Supplier:
AMBEED, INC
Description:
2,2-Difluorocyclopropanemethanol, Purity: 97%, CAS Number: 509072-57-5, Appearance: Colorless to Pale-yellow to Yellow-brown Liquid, Storage: Sealed in dry, 2-8C, Size: 100MG
Catalog Number:
(102988-906)
Supplier:
Adipogen
Description:
Modified base of mammalian DNA. Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis. Important epigenetic marker. Related to bacimethrin .
Supplier:
TCI America
Description:
CAS Number: 50823-90-0
MDL Number: MFCD00061270 Molecular Formula: C8H7F3O2 Molecular Weight: 192.14 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Color: Colorless Specific Gravity (20/20): 1.32
Supplier:
Adipogen
Description:
Antibiotic
Catalog Number:
(80050-000)
Supplier:
MilliporeSigma
Description:
A selective, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd=7nM) both in vitro and in vivo
Catalog Number:
(89356-984)
Supplier:
Genetex
Description:
GT211212 is a broad spectrum antibody which reacts specifically with a wide variety of normal, reactive and neoplastic epithelial tissues. The antibody reacts with simple, cornifying and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues. This antibody can be applied to methanol- or acetone-fixed frozen sections, and to formalin-fixed, paraffin-embedded human tissues. Increased staining intensity is seen following proteolytic treatment of tested tissue (protease iunmaskingi). Similarly embedded methacarn-fixed material is also suitable for cytokeratin demonstration. Anti-Pan Cytokeratin exhibits a wide interspecies cross-reactivity down to xenopus laevis (e.g., human, bovine, rat, and frog). GT211212 may be used for the localization of cytokeratins using various immunochemical assays including direct immunofluorescence using frozen or fixed tissue sections or cultured cells. It may also be used in flow cytometry of normal and neoplastic epithelial cells. Intermediate-sized filaments are abundant cytoplasmic structural proteins in most vertebrate cells.
Supplier:
Adipogen
Description:
Intermediate of the capsaicin biosynthesis. Fatty acid derivative from leucine/valine pathway. Plays a crucial role in determining the efficacy of capsaicin levels. The quantity of (E)-8-Methyl-6-nonenoic acid determines the pungency in placental tissues of Capsicum.
Supplier:
Adipogen
Description:
Chiral reagent used for the resolution of bases. Building block for synthesis.
Catalog Number:
(80051-926)
Supplier:
MilliporeSigma
Description:
A stable, water-soluble nitric oxide (NO) donor (<sup>1</sup>/<sub>2</sub>=27 hours) with properties similar to those of Glyco-SNAP-1 (80051-924). Dissolve in aqueous buffer immediately after use.
Supplier:
AMBEED, INC
Description:
2-Chloro-4-fluorobenzyl alcohol, Purity: 98%, CAS Number: 208186-84-9, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 25g
Supplier:
MP Biomedicals
Description:
Dimethyl Sulfoxide is ideal for use as a cryoprotectant. Also used in chemical reactions, in polymerase chain reactions (PCR) as a PCR cosolvent to help improve yields, especially in long PCR, and as a cryoprotectant vitrification agent for the preservation of cells, tissues and organs. DMSO is used in cell freezing media to protect cells from ice crystal-induced mechanical injury. It is used for frozen storage of primary, sub-cultured, and recombinant heteroploid and hybridoma cell lines, embryonic stem cells (ESC), and hematopoietic stem cells. DMSO is frequently used in the combinations with BSA or fetal bovine serum (FBS). Used to enhance dermal absorption of many chemicals. A solvent for many organic and inorganic compounds including fats, carbohydrates, dyes, resins, and polymers. Used in antifreeze or hydraulic fluids. A cryopreservative for cell cultures. Used in the oxidation of thiols and disulfides to sulfonic acids.
Dimethyl sulfoxide (DMSO) is a highly polar aprotic organic reagent that has exceptional solvent properties for organic and inorganic chemicals Physical Apppearance: Liquid Viscosity: 1.1 centipoises (27 °C) Vapor Density: 2.7 (vs air) Vapor Pressure: 0.55 hPa at 20 °C, 0.42 mmHg (20 °C) Refractive Index: n20/D 1.479(lit.) Solubility: Soluble in water (1 mL DMSO + 1 mL H2O), methanol, acetone, ether, benzene, chloroform
Supplier:
TCI America
Description:
CAS Number: 3143-02-0
MDL Number: MFCD00010273 Molecular Formula: C5H10O2 Molecular Weight: 102.13 Purity/Analysis Method: >96.0% (GC) Form: Clear Liquid Boiling point (°C): 122 Flash Point (°C): 97 Specific Gravity (20/20): 1.04
Catalog Number:
(10426-442)
Supplier:
Bioss
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Catalog Number:
(10426-344)
Supplier:
Bioss
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Supplier:
Adipogen
Description:
Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore (MPTP) activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species (ROS). Induces cell cycle arrest at the G0/G1 and G2/M phase.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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