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2-(2,3-Difluorophenyl)[1,3]dioxolane
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2-(2,3-Difluorophenyl)[1,3]dioxolane
Catalog Number:
(77236-410)
Supplier:
AMBEED, INC
Description:
1-Butoxy-2,3-difluorobenzene, Purity: 98%, CAS Number: 136239-66-2, Appearance: Form: liquid/Colour: Colorless - Slightly pale yellow, Storage: Sealed in dry, Store in freezer, under -20 C, Size: 5g
Catalog Number:
(TCD1838-010G)
Supplier:
TCI America
Description:
CAS Number: 56456-47-4
MDL Number: MFCD00009983 Molecular Formula: C7H6F2O Molecular Weight: 144.12 Purity/Analysis Method: >96.0% (GC) Form: Clear Liquid Flash Point (°C): 90 Specific Gravity (20/20): 1.29
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2',4'-Difluoroacetophenone 99%
Supplier:
Adipogen
Description:
The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely p38alpha, p38beta, p38gamma and p38delta, a.k.a. p38-alpha (MAPK14), -beta (MAPK11), -gamma (MAPK12 / ERK6), and -delta (MAPK13 / SAPK4). The ubiquitously expressed s p38alpha has been the most extensively studied and is believed to be the most physiologically relevant in the regulation of the inflammatory response. The role of the three other isoforms is not currently well understood, however their primary sites of expression are known. Similar to p38alpha, p38beta is also ubiquitously expressed, while p38gamma is expressed predominately in skeletal muscle and p38delta is expressed primarily in the lung, kidney, testis, small intestine and pancreas. The small molecule inhibitor VX-702 is a potent p38 kinase family inhibitor that has been studied for its effects on inflammation and the inflammatory response. VX-702 dose-dependently inhibited the production o IL-6, IL-1beta and TNFalpha (IC(50) = 59, 122 and 99ng/ml, respectively), and in anti-platelet aggregation assays, pre-incubation of platelets with VX-702 (1µM)completely or partially inhibited platelet agonist induced p38 activation (IC(50) = 4 to 20nM). More recently VX-702 has been studied as a potential treatment for rheumatoid arthritis (RA). VX-702 appears to be most effective against MAPK14, followed by MAPK11 and the remaining members of the family, however exact in vitro IC(50) values have not been published. However a large amount of data is available for in vitro growth inhibition assays where VX-702 exhibits poptent activity, having low IC(50) values beginning at ~16nM and ending at < 400µM for the numerous cell lines tested.
Supplier:
Matrix Scientific
Description:
MF=C9H8F2O MW=170.16 Cas=135306-45-5 MDL=MFCD00061142 25G
Supplier:
AMBEED, INC
Description:
2,4-Difluorobenzyl alcohol 96%
Supplier:
Matrix Scientific
Description:
MF=C8H6F2O MW=156.13 Cas=123577-99-1 MDL=MFCD00042489 5G
Catalog Number:
(101787-150)
Supplier:
Matrix Scientific
Description:
MF=C8H6F2O MW=156.13 Cas=364-83-0 MDL=MFCD00151261 100G
Supplier:
Matrix Scientific
Description:
MF=C13H8F2O MW=218.20 Cas=179113-89-4 MDL=MFCD00061140 5G
Supplier:
TCI America
Description:
CAS Number: 13670-99-0
MDL Number: MFCD00000328 Molecular Formula: C8H6F2O Molecular Weight: 156.13 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 79 Flash Point (°C): 76 Specific Gravity (20/20): 1.24
Supplier:
Matrix Scientific
Description:
MF=C7H6F2O MW=144.12 Cas=79538-20-8 MDL=MFCD00010313 5G
Supplier:
Matrix Scientific
Description:
MF=C7H6F2O MW=144.12 Cas=56456-47-4 MDL=MFCD00009983 5G
Catalog Number:
(TCD1885-010G)
Supplier:
TCI America
Description:
CAS Number: 364-83-0
MDL Number: MFCD00151261 Molecular Formula: C8H6F2O Molecular Weight: 156.13 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 80 Flash Point (°C): 66 Specific Gravity (20/20): 1.25
Supplier:
TCI America
Description:
CAS Number: 19064-18-7
MDL Number: MFCD00004603 Molecular Formula: C7H6F2O Molecular Weight: 144.12 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 88 Flash Point (°C): 88 Specific Gravity (20/20): 1.30
Supplier:
TCI America
Description:
CAS Number: 123577-99-1
MDL Number: MFCD00042489 Molecular Formula: C8H6F2O Molecular Weight: 156.13 Purity/Analysis Method: >97.0% (GC) Form: Crystal Boiling point (°C): 95 Melting point (°C): 40 Flash Point (°C): 82
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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