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2-(Difluoromethyl)pyrrolidine+hydrochloride
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2-(Difluoromethyl)pyrrolidine+hydrochloride
Supplier:
MP Biomedicals
Description:
An essential fatty acid, and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides.
Catalog Number:
(77439-970)
Supplier:
Bioss
Description:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
Catalog Number:
(77033-294)
Supplier:
AMBEED, INC
Description:
7-Methoxy-1-naphthylacetonitrile 97%
Catalog Number:
(77439-968)
Supplier:
Bioss
Description:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
Supplier:
MP Biomedicals
Description:
Chloroform is typically used as a solvent and as a cleansing agent. Procedures have been described for the use of chloroform in lambda plaques storage, lambda cDNA storage, the removal of mineral oil from PCR reaction samples, oligonucleotide purification, a hydroxyl radical footprinting protocol, a transcriptional run-on assay protocol, and an overlay assay for beta-galactosidase activity. It has also been used with phenol in such procedures as DNA recovery from polyacrylamide gels, ethidium bromide removal from DNA preparations, lysis protocols for plasmid DNA isolation, RNase removal, and purification of yeast DNA. A protocol describes the use of chloroform in a high-performance thin-layer chromatography protocol for sphingomyelin analysis. Chloroform can also be used in chloroform/methanol mixtures for the isolation of cardiolipids from Geobacillus stearothermophilus and their subsequent MS analysis. The isolation of the bacteriocin amylovorin L471 from Lactobacillus amylovorus DCE 471 in culture broth has been reported, using chloroform/methanol extraction and precipitation in the procedure. Chloroform/2-butanol mixtures can be used for the extraction of steroid sulfates for analysis by nanoelectrospray ionization mass spectrometry.
Catalog Number:
(75831-174)
Supplier:
Restek
Description:
Contains: Acetonitrile (75-05-8); Acrylonitrile (107-13-1); Allyl chloride (3-chloropropene) (107-05-1); Benzene (71-43-2); Bromobenzene (108-86-1); Bromochloromethane (74-97-5); Bromodichloromethane (75-27-4); Bromoform (75-25-2); n-Butylbenzene (104-51-8); sec-Butylbenzene (135-98-8); tert-Butylbenzene (98-06-6); Carbon disulfide (75-15-0); Carbon tetrachloride (56-23-5); Chlorobenzene (108-90-7); 2-Chloroethanol (107-07-3); Chloroform (67-66-3); Chloroprene (2-chloro-1,3-butadiene) (126-99-8); 2-Chlorotoluene (95-49-8); 4-Chlorotoluene (106-43-4); Dibromochloromethane (124-48-1); 1,2-Dibromo-3-chloropropane (DBCP) (96-12-8); 1,2-Dibromoethane (EDB) (106-93-4); Dibromomethane (74-95-3); 1,2-Dichlorobenzene (95-50-1); 1,3-Dichlorobenzene (541-73-1); 1,4-Dichlorobenzene (106-46-7); cis-1,4-Dichloro-2-butene (1476-11-5); trans-1,4-Dichloro-2-butene (110-57-6); 1,1-Dichloroethane (75-34-3); 1,2-Dichloroethane (107-06-2); 1,1-Dichloroethene (75-35-4); cis-1,2-Dichloroethene (156-59-2); trans-1,2-Dichloroethene (156-60-5); 1,2-Dichloropropane (78-87-5); 1,3-Dichloropropane (142-28-9); 2,2-Dichloropropane (594-20-7); 1,1-Dichloropropene (563-58-6); cis-1,3-Dichloropropene (10061-01-5); trans-1,3-Dichloropropene (10061-02-6); Diethyl ether (ethyl ether) (60-29-7); 1,4-Dioxane (123-91-1); Ethylbenzene (100-41-4); Ethyl methacrylate (97-63-2); Hexachloro-1,3-butadiene (87-68-3); Iodomethane (methyl iodide) (74-88-4); Isobutyl alcohol (2-methyl-1-propanol) (78-83-1); Isopropylbenzene (cumene) (98-82-8); 4-Isopropyl toluene (p-Cymene) (99-87-6); Methacrylonitrile (126-98-7); Methyl acrylate (96-33-3); Methyl methacrylate (80-62-6); Methylene chloride (dichloromethane) (75-09-2); Naphthalene (91-20-3); Nitrobenzene (98-95-3); 2-Nitropropane (79-46-9); Pentachloroethane (76-01-7); Propionitrile (107-12-0); n-Propylbenzene (103-65-1); Styrene (100-42-5); 1,1,1,2-Tetrachloroethane (630-20-6); 1,1,2,2-Tetrachloroethane (79-34-5); Tetrachloroethene (127-18-4); Tetrahydrofuran (109-99-9); Toluene (108-88-3); 1,2,3-Trichlorobenzene (87-61-6); 1,2,4-Trichlorobenzene (120-82-1); 1,1,1-Trichloroethane (71-55-6); 1,1,2-Trichloroethane (79-00-5); Trichloroethene (79-01-6); 1,2,3-Trichloropropane (96-18-4); 1,1,2-Trichlorotrifluoroethane (CFC-113) (76-13-1); 1,2,4-Trimethylbenzene (95-63-6); 1,3,5-Trimethylbenzene (108-67-8); m-Xylene (108-38-3); o-Xylene (95-47-6); p-Xylene (106-42-3)
Supplier:
MP Biomedicals
Description:
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is a colorless, volatile chlorinated organic solvent whose vapors have a narcotic effect.
Chloroform is use as a solvent for fats, oils, rubber, alkaloids, waxes, gutta-percha, resins; as cleansing agent; in fire extinguishers to lower the freezing temperature of carbon tetrachloride. Procedures have been described for the use of chloroform in lambda plaques storage, lambda cDNA storage, the removal of mineral oil from PCR reaction samples, oligonucleotide purification, a hydroxyl radical footprinting protocol, a transcriptional run-on assay protocol, and an overlay assay for beta-galactosidase activity. It has also been used with phenol in such procedures as DNA recovery from polyacrylamide gels, ethidium bromide removal from DNA preparations, lysis protocols for plasmid DNA isolation, RNase removal, and purification of yeast DNA. A protocol describes the use of chloroform in a high-performance thin-layer chromatography protocol for sphingomyelin analysis. Chloroform can also be used in chloroform/methanol mixtures for the isolation of cardiolipids from Geobacillus stearothermophilus and their subsequent MS analysis. The isolation of the bacteriocin amylovorin L471 from Lactobacillus amylovorus DCE 471 in culture broth has been reported, using chloroform/methanol extraction and precipitation in the procedure. Chloroform/2-butanol mixtures can be used for the extraction of steroid sulfates for analysis by nanoelectrospray ionization mass spectrometry. Physical Appearance: Liquid Vapor Density: 4.36 (air = 1) (Lit.) Vapor Pressure: 211 hPa at 20 °C(Lit.) Refractive Index: n20/D 1.445(Lit.) Solubility: Soluble in water (1 mL/200 mL water); miscible with ethanol, benzene, ether, petroleum ether, carbon tetrachloride, carbon disulfide, oils.
Catalog Number:
(SX5311-A10)
Supplier:
SPEX CERTIPREP LLC
Description:
Pesticides, PCBs and Herbicides
The EPA is tasked with the monitoring of environmental systems as they pertain to contamination and human health. The methods issued by the EPA are created to respond to specific toxins or persistent organic pollutants (POPs) found in environmental samples such as soil, source water, drinking water, and waste. In particular, pollutants such as polychlorinated biphenyls (PCBs), which were in widespread industrial use up until their restriction, are of concern due to their stable and persistent nature in the environment. Another group of chemicals of high concern is the hundreds of commercial pesticides and herbicides in use in the world today. Pesticides, from algaecides to virucides, are used in large quantities in industrial and private agriculture. The concern over human pesticide exposure over the past few decades has led to extensive monitoring of these pesticides. It has been reported that over 98% of insecticides and 95% of herbicides affect areas other than their intended target product. It is essential that monitoring agencies have accurate standard mixes to measure the pesticide levels in the environment. Many new pesticides are now being tested using highly sensitive LC/MS techniques, in addition to traditional GC techniques, to determine minute amounts of residue in environmental samples and food products. At SPEX CertiPrep, we facilitate ease of monitoring and testing of pesticides by creating pesticide test mixes to suit your monitoring needs. SPEX CertiPrep is the leader in offering pesticide standards designed to work within EPA, AOAC and FDA analytical testing methods using all of the leading analytical techniques: LC, LC/MS, GC, and GC/MS. Many pesticide standard mixes are readily available in our catalog along with a large list of single pesticide standards. In addition, custom pesticide mixes can be made to your specifications to create a mix that meets your needs. US EPA Method 531 is an analytical method for the monitoring of n-methylcarbamoyloximes and n-methylcarbamates in drinking water and ground water by HPLC and a fluorescence detector
Catalog Number:
(TCM0140-005ML)
Supplier:
TCI America
Description:
CAS Number: 5616-32-0
MDL Number: MFCD00058964
Molecular Formula: C3H6N2
Molecular Weight: 70.10
Purity/Analysis Method: <gt/>98.0% (GC,T)
Form: Clear Liquid
Boiling point (°C): 65
Specific Gravity (20/20): 0.92
Storage Temperature: <lt/>0°C
Catalog Number:
(TCN0049-005G)
Supplier:
TCI America
Description:
CAS Number: 14271-86-4
MDL Number: MFCD00060239 Molecular Formula: C12H7NO Molecular Weight: 181.19 Purity/Analysis Method: >98.0% (GC,N) Form: Crystal Boiling point (°C): 182 Melting point (°C): 100
Supplier:
TCI America
Description:
1-(tert-Butoxycarbonyl)-4-piperidinecarboxaldehyde, Purity: >95.0%(GC), Cas number: 137076-22-3, Molecular Formula: C11H19NO3, Molecular Weight: 213.28, Synonyms: 1-Boc-4-formylpiperidine, 1-Boc-4-piperidinecarboxaldehyde, Size: 1G
Catalog Number:
(AAA18906-06)
Catalog Number:
(BT225775-100G)
Supplier:
BeanTown Chemical
Description:
CAS: 58632-95-4; EC No: 261-370-9; MDL No: MFCD00001863; RTECS: DA0513600
UN No: UN3439; Haz Class: 6.1; Packing Group: III
Crystalline; Molecular Formula: C13H14N2O3; MW: 246.26
Melting Point: 85-88°
Moisture Sensitive
Catalog Number:
(103671-390)
Supplier:
Matrix Scientific
Description:
(4-FORMYL-3-METHOXYPHENOXY) 088337-1G
Catalog Number:
(77924-488)
Supplier:
AOB CHEM USA
Description:
2-(2-FORMYL-6-METHOXYPHENOXY)ACETO 25G
Catalog Number:
(77878-546)
Supplier:
AMBEED, INC
Description:
2-(4-FORMYL-3-METHOXYPHENOXY)ACETIC 1G
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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