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2-(2-Methylphenyl)ethanol
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2-(2-Methylphenyl)ethanol
Supplier:
MP Biomedicals
Description:
Butylated Hydroxyanisole is an antioxidant. It is a mixture of 2- and 3-tertiary-butyl-4-hydroxyanisole.
Supplier:
MP Biomedicals
Description:
Pyridoxine Hydrochloride is one of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals).
Supplier:
MP Biomedicals
Description:
Potassium Iodide is known as Potassium Salt of Hydriodic Acid [HI]. Its Ionic form is K+ I-, and iodide ion being mild reducing agent, it can be easily oxidized to Iodine by powerful oxidizing agent like chlorine.
Catalog Number:
(80055-978)
Supplier:
MilliporeSigma
Description:
A natural dietary compound reported to have anticarcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID50=3.7µM). Inhibits Ca2+-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.
Supplier:
Adipogen
Description:
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to <lt/>200nM.
Supplier:
Adipogen
Description:
Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative agent. Suppresses metastasis. Apoptosis inducer. Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway. Anti-leishmanial (IC50 = 0.150µM). Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC50=0.51µM). Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.
Supplier:
Thermo Scientific Chemicals
Description:
As a flux in galvanizing steel sheet, in batteries, to clean soldering irons, analytical lab reagent, in washing powders, electroplating, lustering cotton
Supplier:
Adipogen
Description:
Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. Potential antiviral and anti-Alzheimer's agent.
Supplier:
MP Biomedicals
Description:
Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin).
Supplier:
MP Biomedicals
Description:
Vincristine Sulfate, a dimeric Vinca alkaloid. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses.
Supplier:
Adipogen
Description:
Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.
Supplier:
Adipogen
Description:
Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Supplier:
Adipogen
Description:
Potent, competitive and reversible cysteine, serine and threonine protease inhibitor. Inhibits calpain, kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit pepsin, elastase, renin, cathepsins A and D, thrombin or alpha-chymotrypsin. Used to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. Shown to inhibit activation-induced programmed cell death. Antioxidant and anti-inflammatory agent. Widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Catalog Number:
(102991-284)
Supplier:
Adipogen
Description:
CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.
Supplier:
Adipogen
Description:
Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC(50) values below 1µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases PLK2 and PLK3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers.
Supplier:
Adipogen
Description:
JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and aurora kinases. It demonstrates highest potency on CDK1/2 with IC(50) values of 9nM and 4nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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