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tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate hcl
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tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate hcl
Supplier:
Thermo Scientific Chemicals
Description:
250g CAS: 143-33-9, MDL: MFCD00003523
Supplier:
Rockland Immunochemical
Description:
Recombinant Mouse IL-33 control protein
Catalog Number:
(AAH58726-03)
Supplier:
Thermo Scientific Chemicals
Description:
1g CAS: 28036-33-1, MDL: MFCD06660421
Supplier:
AMBEED, INC
Description:
3,3-Dibromo-1,1,1-trifluoropropan-2-one, Purity: 95%, CAS Number: 431-67-4, Appearance: Liquid, Storage: Inert atmosphere, 2-8 C, Size: 10g
Supplier:
TCI America
Description:
CAS Number: 6313-33-3
MDL Number: MFCD00012865
Molecular Formula: CH4N2
Molecular Weight: 80.52
Purity/Analysis Method: <gt/>97.0% (T)
Form: Crystal
Melting point (°C): 85
Supplier:
Shenandoah Biotechnology
Description:
Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.
Catalog Number:
(103259-666)
Supplier:
Southern Biotechnology
Description:
Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.
Catalog Number:
(77749-770)
Supplier:
AMBEED, INC
Description:
5-Bromo-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine ≥97%
Supplier:
Adipogen
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
Catalog Number:
(76825-602)
Supplier:
AMBEED, INC
Description:
5,6-Dimethoxy-3,3-dimethyl-2,3-dihydro-1H-inden-1-one, Purity: 97%, CAS Number: 4136-26-9, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 1G
Catalog Number:
(76483-542)
Supplier:
AAT BIOQUEST INC
Description:
DiI, DiO, DiS, DiD and DiR dyes are a family of lipophilic fluorescent stains for labeling membranes and other hydrophobic structures.
Catalog Number:
(102897-594)
Supplier:
Matrix Scientific
Description:
3, 3-Difluorocyclobutane-1, 1-Dicarboxylic 1-Isopropyl Ester, MF=C9H12F2O4, MW=222.19, CAS=1225532-90-0, 1G
Catalog Number:
(TCD1541-025G)
Supplier:
TCI America
Description:
CAS Number: 5331-87-3
MDL Number: MFCD00059591 Molecular Formula: C14H6Cl2N2O2 Molecular Weight: 305.11 Purity/Analysis Method: >95.0% (T) Form: Crystal Melting point (°C): 168 Storage Temperature: 0-10°C
Supplier:
Matrix Scientific
Description:
MF=C8H12N2O2 MW=168.20 CAS=175277-33-5 MDL=MFCD00085137 1G
Supplier:
Matrix Scientific
Description:
MF=C6H14NO5P MW=211.16 CAS=20120-33-6 MDL=MFCD00468093 1G
Supplier:
Matrix Scientific
Description:
MF=C16H16O3 MW=256.30 Cas=60186-33-6 MDL=MFCD00615145 5G
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