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5-[2-(Trifluoromethyl)phenyl]cyclohexane-1,3-dione
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5-[2-(Trifluoromethyl)phenyl]cyclohexane-1,3-dione
Supplier:
Bachem Americas
Description:
Sequence: H-Glu(OtBu)-OtBu · HCl
Catalog Number:
(10303-852)
Supplier:
Bioss
Description:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
Supplier:
Corning
Description:
Tris-HCl buffer has many applications in molecular biology work, including use in nucleic acid purification
Supplier:
AMBEED, INC
Description:
Ethyl 2-Amidinoacetate Hydrochloride, Purity: 97%, CAS Number: 57508-48-2, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 1g
Catalog Number:
(76012-208)
Supplier:
Prosci
Description:
The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.
Supplier:
Adipogen
Description:
Potent inhibitor of ethylene synthesis in plants acting at the level of 1-aminocyclopropanecarboxylic acid synthase.
Supplier:
Thermo Scientific Chemicals
Description:
Inhibits bacterial mucopeptide synthesis.
Supplier:
TCI America
Description:
CAS Number: 114622-81-0
MDL Number: MFCD00065554 Molecular Formula: C11H22N4O4 Molecular Weight: 310.78 Purity/Analysis Method: >98.0% (N) Form: Crystal
Catalog Number:
(101834-112)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 032616-500MG , MDL Number: MFCD11506412
Supplier:
ALADDIN SCIENTIFIC
Description:
Methyl-4-aminobicyclo[2.2.2]octane-1-carboxylate ≥98%
Supplier:
ALADDIN SCIENTIFIC
Description:
Amiloride ? HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein.A calcium channel andsodium channel protein inhibitor
Catalog Number:
(76817-406)
Supplier:
AMBEED, INC
Description:
H-Thr(Bzl)-OH.HCl, Purity: 98%, CAS Number: 60856-51-1, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 250MG
Catalog Number:
(100271-454)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 53956-05-1 1gm H-2-Abu-OtBu. HCI 195.7 Room temperature.
Supplier:
Ricca Chemical
Description:
Fuchsin-Carbol, Ziehl-Neelsen Formulation, for Staining Acid Fast Organisms
Supplier:
Adipogen
Description:
Naturally occurring carnitine derivative formed by carnitine acetyltransferase during beta-oxidation of uneven chain fatty acids, with high affinity for muscular carnitine transferase. Increases cellular carnitine content, allowing free fatty acid transport into the mitochondria. Stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. Important for mitochondrial metabolism and energy regulation. Regulates the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. Selectively inhibits in vitro and ex vivo platelet-activating factor (PAF) synthesis from human neutrophils. Antioxidant. Shows free radical scavenging activity. Decreases the expression of inducible nitric oxide synthase (iNOS/NOS II) and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells. Shows beneficial cardiovascular effects. Improves body weight, food intake, adiposity and insulin resistance in Type 2 diabetes. Stimulates endothelial nitric oxide (eNOS/NOS III) and increased NO production, via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt.
Catalog Number:
(75928-160)
Supplier:
Rockland Immunochemical
Description:
GOLGA5 (Golgi autoantigen, subfamily A, member 5), also known as GOLGA84, RFG5 (RET-fused gene 5 protein) or GOLIM5, is a ubiquitously expressed single-pass type II coiled-coil membrane protein that is involved in maintaining Golgi structure (1). It is localized to the Golgi apparatus and predominantly found on membranes at the cis side of the Golgi stack (1,2). As a mitotic phosphoprotein, GOLGA5 binds to active Rab 1 and associates with CASP (an isoform of CDP) in a golgin-tethering complex that is believed to play a role in intra-Golgi retrograde transport (3,4). Defects in GOLGA5 are a cause of thyroid papillary carcinoma (TPC) (5).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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