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3-(Hydroxymethyl)-1-methyl-1H-indazole
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3-(Hydroxymethyl)-1-methyl-1H-indazole
Supplier:
AMBEED, INC
Description:
Methyl-6-(hydroxymethyl)picolinate 97%
Supplier:
AMBEED, INC
Description:
Methyl 5-(hydroxymethyl)nicotinate 97%
Catalog Number:
(10300-352)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
Catalog Number:
(AAH63793-03)
Supplier:
Thermo Scientific Chemicals
Description:
Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
Supplier:
AMBEED, INC
Description:
(S)-N-(2-Chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide, Purity: 97%, CAS Number: 2225819-06-5, Appearance: Solid, Storage: Sealed in dry, Store in freezer, under -20C, Size: 1MG
Catalog Number:
(10300-354)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
Supplier:
TCI America
Description:
CAS Number: 33457-48-6
MDL Number: MFCD00191661 Molecular Formula: C5H8N2O2 Molecular Weight: 128.13 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 162
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 046554-1G , MDL Number: MFCD06202903
Supplier:
AMBEED, INC
Description:
2-(Hydroxymethyl)-5-(trifluoromethyl)benzimidazole 95%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
(1H-Imidazol-4-yl)methanol hydrochloride 99%
Supplier:
AMBEED, INC
Description:
5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-ylamino]-2-methylbenzenesulfonamide 99%
Supplier:
Thermo Scientific Chemicals
Description:
5-(Hydroxymethyl)pyrimidine-2,4-dione Uracil-5-methanol. Grade: 98, Melting Point C>300*. Boiling Point C: NA. C5H6N2O3. 4433-40-3.
Catalog Number:
(77168-220)
Supplier:
AMBEED, INC
Description:
N'-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide, Purity: 95%, CAS Number: 17331-13-4, Appearance: White to off-white Solid, Storage: Sealed in dry, 2-8 C, Size: 1g
Catalog Number:
(10300-356)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
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