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3-Picolyl+isothiocyanate+hydrobromide
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3-Picolyl+isothiocyanate+hydrobromide
Catalog Number:
(10240-980)
Supplier:
Bioss
Description:
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Catalog Number:
(10267-190)
Supplier:
Bioss
Description:
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Catalog Number:
(10247-866)
Supplier:
Bioss
Description:
Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy.
Catalog Number:
(10365-618)
Supplier:
Bioss
Description:
The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Catalog Number:
(100243-194)
Supplier:
Southern Biotechnology
Description:
The monoclonal antibody I21/7 reacts with the α subunit of mouse and human CD11a, also known as LFA-1, and a member of the integrin family of cell adhesion molecules. The antigen is expressed on thymocytes, T and B lymphocytes, and on non-lymphoid cells in the bone marrow. CD11a appears to be an essential component for T-cell activation by antigen-presenting cells and is important for cell-mediated killing. Costimulatory signaling by LFA-1 is achieved by pairing with its ligand, CD54/ICAM-1.
Catalog Number:
(75844-090)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The HI130 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45. It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.
Catalog Number:
(103368-974)
Supplier:
Novus Biologicals
Description:
The Apolipoprotein E R2 / ApoE R2 Antibody [FITC] from Novus Biologicals is a rabbit polyclonal antibody to Apolipoprotein E R2 / ApoE R2. This antibody reacts with human, mouse, chicken. The Apolipoprotein E R2 / ApoE R2 Antibody [FITC] has been validated for the following applications: Immunocytochemistry / Immunofluorescence.
Catalog Number:
(10765-720)
Supplier:
Prosci
Description:
The 1A8 monoclonal antibody specifically reacts with the 21-25 kDa glycophosphatidylinositol-anchored protein known as Ly-6G, expressed by the granulocytes from the bone marrow and periphery neutrophils. Ly-6G and Ly-6C form the Granulocyte Receptor-1 antigen (GR-1). The binding of the 1A8 antibody to the Ly-6G can be blocked by another antibody, RB6-8C5, which also recognizes Ly-6C. While 1A8 is specific for only Ly-6G, RB6-8C5 also binds to Ly-6C.
Catalog Number:
(10766-072)
Supplier:
Prosci
Description:
The 5E10 monoclonal antibody specifically reacts with human CD90, also known as thymus cell antigen-1 (Thy-1). CD90 is a 25-37 kDA GPI-anchored protein is the smallest member of the Ig superfamily. CD90 is expressed on thymocytes, neurons, mesenchymal stem cells, hematopoietic stem cells, NK cells, and follicular dendritic cells and plays a role in inflammation, metastasis, apoptosis, and nerve regeneration. The 5E10 antibody can be used for the enriching high proliferative potential colony-forming cells (HIPP-CFC).
Catalog Number:
(10294-698)
Supplier:
Bioss
Description:
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
Catalog Number:
(103264-254)
Supplier:
Novus Biologicals
Description:
The Goat anti-Mouse IgM Secondary Antibody [FITC] from Novus Biologicals is a goat polyclonal antibody to IgM. This antibody reacts with mouse. The Goat anti-Mouse IgM Secondary Antibody [FITC] has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103264-236)
Supplier:
Novus Biologicals
Description:
The Sheep anti-Canine IgG2 Secondary Antibody [FITC] from Novus Biologicals is a sheep polyclonal antibody to IgG2. This antibody reacts with canine. The Sheep anti-Canine IgG2 Secondary Antibody [FITC] has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(10356-334)
Supplier:
Bioss
Description:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
Catalog Number:
(10233-776)
Supplier:
Bioss
Description:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Catalog Number:
(103262-106)
Supplier:
Novus Biologicals
Description:
The Goat anti-Feline IgM Secondary Antibody [FITC] from Novus Biologicals is a goat polyclonal antibody to IgM. This antibody reacts with feline. The Goat anti-Feline IgM Secondary Antibody [FITC] has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(10363-638)
Supplier:
Bioss
Description:
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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