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4,6-Dimethoxy-5-nitropyrimidine
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4,6-Dimethoxy-5-nitropyrimidine
Catalog Number:
(103056-276)
Supplier:
Sepax Technologies
Description:
COLUMN HPLC POLYRP-NP 1.7UM 4.6 X 250MM
Catalog Number:
(103057-148)
Supplier:
Sepax Technologies
Description:
COLUMN HPLC PROTEOMIX SAX-NP 4.6 X 50MM
Catalog Number:
(103052-726)
Supplier:
Sepax Technologies
Description:
COLUMN ANTIBODIX NP1.7 1.7UM 4.6 X 30 MM
Catalog Number:
(97057-184)
Supplier:
MicroSolv Technology Corp
Description:
VIALS 10ML 46 X 23MM CRP CL BL
Supplier:
Spectrum Chemicals
Description:
3,4-Dimethoxybenzoic Acid, Purity: 98%, Cas number: 93-07-2, Molecular Formula: C9H10O4, Molecular Weight: 182.18, Color/Form: White, Pale yellow to reddish-amber/Solid Crystal powder, Synonym: Veratric Acid, Protocatechuic Acid Dimethyl Ether, Size: 100GM
Catalog Number:
(76345-352)
Supplier:
RPI
Description:
CYTIDINE CAS : 65-46-3 MW: 243.22 5G
Catalog Number:
(MSPP-87522)
Supplier:
CHIRAL TECHNOLOGIES INC MS
Description:
COLUMN CHIRALPAK IG-3 3MIC 4.6 X 50 MM
Catalog Number:
(TCD1111-025G)
Supplier:
TCI America
Description:
CAS Number: 93-02-7
MDL Number: MFCD00003314 Molecular Formula: C9H10O3 Molecular Weight: 166.18 Purity/Analysis Method: >97.0% (GC) Form: Crystal Boiling point (°C): 270 Melting point (°C): 50 Flash Point (°C): 109
Catalog Number:
(76286-580)
Supplier:
G-Biosciences
Description:
RIFAMPICIN USP GRADE CAS 13292-46-1 1G
Supplier:
AMBEED, INC
Description:
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride, Purity: 98%, CAS number: 183322-45-4, Appearance: Form: Crystal - Powder / Colour: Very pale yellow - Pale reddish yellow, Storage: Sealed in dry, Room Temperature, Size: 5MG
Catalog Number:
(76286-584)
Supplier:
G-Biosciences
Description:
RIFAMPICIN USP GRADE CAS 13292-46-1 5G
Catalog Number:
(TCD1729-5G)
Supplier:
TCI America
Description:
CAS Number: 17587-22-3
MDL Number: MFCD00000435 Molecular Formula: C10H11F7O2 Molecular Weight: 296.18 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Flash Point (°C): 53 Specific Gravity (20/20): 1.30
Catalog Number:
(10813-996)
Supplier:
Prosci
Description:
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. Ref.40 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.46 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Supplier:
AOB CHEM USA
Description:
1,5-Difluoro-2,4-dimethoxybenzene ≥97%
Supplier:
TCI America
Description:
CAS Number: 2785-98-0
MDL Number: MFCD00002436
Molecular Formula: C9H10O4
Molecular Weight: 182.18
Purity/Analysis Method: <gt/>98.0% (GC,T)
Form: Crystal
Melting point (°C): 78
Supplier:
ALADDIN SCIENTIFIC
Description:
Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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