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Catalog Number:
(103008-176)
Supplier:
Anaspec Inc
Description:
This 1-21 amino acid histone H3 peptide has a trimethylated lysine at position 9. This form of histone methylation is characterized as being enriched around transcription start sites. It has been observed that certain family members of the JMJ enzyme (Jumonji C domain-containing oxygenases) that play a role in regulating the methylation status of histone H3 lysine residues exhibits selectivity towards this peptide.
Sequence:ARTKQTAR-K(Me3)-STGGKAPRKQLA MW:2296.6 Da % peak area by HPLC:95 Storage condition:-20° C
Supplier:
Adipogen
Description:
ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <lt/>1 nM) and also shows a very high specificity over Mcl-1 and A1.
Supplier:
TCI America
Description:
CAS Number: 838-07-3
MDL Number: MFCD00006549 Molecular Formula: C10H15N3O4 Molecular Weight: 241.25 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 193 Specific rotation [a]20/D: 44 deg (C=1.4, H2O)
Supplier:
MP Biomedicals
Description:
Antibiotic. Cefadroxil was used to investigate its interaction with hPEPT1 and dipeptide Gly-Sar on basis of steady-state and presteady-state analysis thus testing the hypothesis that variations in drug response among individuals are caused by alterations in the genes involved in drug absorption.
Catalog Number:
(100218-364)
Supplier:
Teknova
Description:
Sarkosyl (sodium lauroyl sarcosinate) is an anionic detergent that is less denaturing than SDS. Uses include solubilization of membranes and cell lysis for extraction of RNA.
Catalog Number:
(76483-188)
Supplier:
AAT BIOQUEST INC
Description:
Quin-2 binds calcium tightly and resembles calcium chelator EGTA in ability to bind calcium much more tightly than magnesium.
Catalog Number:
(77249-150)
Supplier:
AMBEED, INC
Description:
Cyclopentyl (S)-2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate, Purity: 98%, CAS Number: 238750-77-1, Appearance: White to off-white solid, Storage: Keep in dark place, Sealed in dry, Store in freezer, under -20 C, Size: 1mg
Catalog Number:
(103508-398)
Supplier:
Acros Organics
Description:
Adenosine 5'-monophosphate, Cas number: 61-19-8, Purity: 99%, Molecular Weight: 347.22, Molecular Formula: C10 H14 N5 O7 P, Form: Solid, Color: Red brown, Synonyms: 5'-Adenylic acid, 5'-AMP, Size: 100G
Catalog Number:
(10751-292)
Supplier:
Prosci
Description:
EZH2 Antibody: EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Acarbose 95%
Catalog Number:
(76107-846)
Supplier:
Bioss
Description:
Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutation in the genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 3B (LRRC3B), also designated LRP15, is a 259 amino acid protein that contains 3 LRR repeats. The gene encoding LRRC3B is a tumor suppressor gene that is regulated by DNA methylation. Decreased expression of LRRC3B has been shown in colorectal cancer and gastric cancer, making LRRC3B a candidate marker for those cancers.
Catalog Number:
(77438-234)
Supplier:
Bioss
Description:
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Catalog Number:
(89358-802)
Supplier:
Genetex
Description:
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq]
Supplier:
ALADDIN SCIENTIFIC
Description:
Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adultsA serotonin 5HT1B /1D-receptor agonist used for treatment of migraines.
Supplier:
AMBEED, INC
Description:
β-Nicotinamide adenine dinucleotide phosphate (β-NADP) 98%
Supplier:
Anaspec Inc
Description:
This peptide is Histone H3 amino acid residues 21 to 44 tri-methylated at Lys-27 with an addidtional C-terminal glycine followed by a biotinylated lysine. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-GK(Biotin) MW:2959.5 Da % peak area by HPLC:95 Storage condition:-20° C
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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