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(5-Bromobenzo[b]thiophen-3-yl)methanamine+hydrochloride
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(5-Bromobenzo[b]thiophen-3-yl)methanamine+hydrochloride
Catalog Number:
(102841-840)
Supplier:
Matrix Scientific
Description:
(2-Amino-1,3-thiazol-5-yl)methanol ≥97%
Supplier:
AMBEED, INC
Description:
(R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine ≥98%
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Supplier:
AMBEED, INC
Description:
1-((2-((2-((7-Chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one, Purity: 98%, CAS Number: 1859141-26-6, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 1mg
Supplier:
AMBEED, INC
Description:
2-(3-(4-((1H-Indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, Purity: 99%, CAS Number: 911417-87-3, Appearance: White to yellow or gray powder or crystals, Storage: Keep in dark place, Sealed in dry, 2-8 deg C, Size: 10mg
Supplier:
AMBEED, INC
Description:
2-Amino-3-(8-hydroxyquinolin-5-yl)propanoic acid dihydrochloride, Purity: 97%, CAS Number: 23218-76-0, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 100MG
Supplier:
AMBEED, INC
Description:
4-((6-Aminopyrimidin-4-yl)amino)benzenesulfonamide hydrochloride, Purity: 97%, CAS Number: 21886-12-4, Appearance: White to light-yellow solid, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 10mg
Catalog Number:
(77620-544)
Supplier:
AMBEED, INC
Description:
N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride 98+%
Supplier:
MilliporeSigma
Description:
For molecular biology. Prepared with diethyl pyrocarbonate for RNA applications. DNase-, RNase-, and protease-free.
Supplier:
Thermo Fisher Scientific Chemicals Inc.
Description:
Chelating agent used in many enzyme buffers and as an enzyme inactivator at high concentrations.
Supplier:
AMBEED, INC
Description:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-methoxyphenyl)diphenylmethyl)amino)hexanoic acid 95%, Ambeed.Inc
Supplier:
AMBEED, INC
Description:
Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride 97%, Ambeed.Inc
Supplier:
AMBEED, INC
Description:
4-Amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, Purity: 98%, CAS Number: 1446113-23-0, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 10MG
Supplier:
AMBEED, INC
Description:
(3-Amino-1H-pyrazol-4-yl)(thiophen-2-yl)methanone, Purity: 95%, CAS number: 96219-87-3, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, 2-8C, Size: 1G
Supplier:
Matrix Scientific
Description:
MF=C13H16F3N3O MW=287.29 CAS=914348-88-2 MDL=MFCD04117870 5G
Supplier:
MP Biomedicals
Description:
Ethylenediamine Tetraacetic Acid is a chelator of divalent cations. It also inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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