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4-Iodo-7H-pyrrolo[2,3-d]pyrimidine
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4-Iodo-7H-pyrrolo[2,3-d]pyrimidine
Supplier:
Adipogen
Description:
PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.
Supplier:
Adipogen
Description:
XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM)
Supplier:
TCI America
Description:
CAS Number: 18592-13-7
MDL Number: MFCD00010095
Molecular Formula: C5H5ClN2O2
Molecular Weight: 160.56
Purity/Analysis Method: <gt/>98.0% (HPLC,T)
Form: Crystal
Supplier:
BeanTown Chemical
Description:
CAS: 207742-76-5; EC No: 256-446-3; MDL No: MFCD00012789
Powder; Molecular Formula: C4H7N5·H2SO4·xH2O; MW: 223.22 (anhydrous)
Melting Point: <gt/>300°
Supplier:
Adipogen
Description:
Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.
Catalog Number:
(77405-340)
Supplier:
APOLLO SCIENTIFIC
Description:
4-Chloro-7-azaindole
Supplier:
AMBEED, INC
Description:
4-Chloro-7-azaindole 98%, Ambeed.Inc
Catalog Number:
(101777-080)
Supplier:
AMBEED, INC
Description:
7H-Benzo[c]carbazole 97%
Supplier:
AMBEED, INC
Description:
6-Chloro-7-methyl-7H-purine ≥96%
Supplier:
AMBEED, INC
Description:
2-(Methylamino)-1H-purin-6(7H)-one 98%
Supplier:
AMBEED, INC
Description:
6-Chloro-7H-purin-8(9H)-one 95+%
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Magnesium Sulfate, 7-Hydrate, (For Parenteral Use), USP - GenAR®
Supplier:
AMBEED, INC
Description:
2-Chloro-7H-purin-6-amine 97%
Supplier:
AMBEED, INC
Description:
8-Methyl-7H-purin-6-amine, Purity: 98%, CAS number: 22387-37-7, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, 2-8C, Size: 250MG
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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