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4-Iodo-7H-pyrrolo[2,3-d]pyrimidine
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4-Iodo-7H-pyrrolo[2,3-d]pyrimidine
Supplier:
AMBEED, INC
Description:
Baricitinib 99%, Ambeed.Inc
Supplier:
Matrix Scientific
Description:
MF=C14H8N4O2 MW=264.25 Cas=741686-49-7 ,1G
Supplier:
TCI America
Description:
CAS Number: 3680-69-1
MDL Number: MFCD01686865 Molecular Formula: C6H4ClN3 Molecular Weight: 153.57 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 188
Catalog Number:
(BT143020-1G)
Supplier:
BeanTown Chemical
Description:
CAS: 3680-69-1; MDL No: MFCD01686865
Crystalline/Powder; Molecular Formula: C6H4ClN3; MW: 153.57
Melting Point: 188-194°
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
6-Chloro-7-deazapurine 97%
Supplier:
AMBEED, INC
Description:
Ruxolitinib 98%
Catalog Number:
(102987-452)
Supplier:
Adipogen
Description:
Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE). By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
Supplier:
AMBEED, INC
Description:
NVP-AEW541 ≥99%
Supplier:
MORAVEK BIOCHEMICALS MS
Description:
7-Deaza-2'-deoxyadenosine ≥98% (by HPLC) MORpure™
Supplier:
MORAVEK BIOCHEMICALS MS
Description:
7-Deaza-2'-deoxyguanosine ≥98% (by HPLC) MORpure™
Supplier:
Adipogen
Description:
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.
Supplier:
Adipogen
Description:
Baricitinib is a selective JAK1 and JAK2 inhibitor. IC(50) values are 5.9nm for JAK1, and 5.7nM for JAK2. In cell based assays Baricitinib/INCB-28050 demonstrated inhibition of intracellular signaling of multiple pro-inflammatory cytokines including IL-6 and IL-23 at concentrations of <lt/> 50nM, and also showed good efficacy in a number of animal models at doses of 10mg/kg and below. Baricitinib is in Phase III development as a potential treatment for rheumatoid arthritis. It is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy
Supplier:
Adipogen
Description:
INCB018424 is a JAK inhibitor with an IC(50) values of 2.7nM and 4.5nM, respectively for JAK1 and JAK2.
Supplier:
Adipogen
Description:
Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Supplier:
Adipogen
Description:
Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Supplier:
Adipogen
Description:
Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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