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6-(Aminomethyl)-1H-pyrimidin-4-one+dihydrochloride
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6-(Aminomethyl)-1H-pyrimidin-4-one+dihydrochloride
Supplier:
APOLLO SCIENTIFIC
Description:
5-(Pentafluorothio)-1H-benzimidazole
Supplier:
AMBEED, INC
Description:
5-Methylfuran-2(5H)-one 95%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
3-Ethoxy-2-cyclohexen-1-one 99%
Supplier:
APOLLO SCIENTIFIC
Description:
5,5,5-Trifluoropentan-2-one 98%
Catalog Number:
(77686-498)
Supplier:
AMBEED, INC
Description:
6-Bromo-4-fluoroindolin-2-one ≥98%
Catalog Number:
(101784-772)
Supplier:
Matrix Scientific
Description:
MF=C12H10F8O3S MW=386.26 Cas=2264-00-8 MDL=MFCD00378586 ,5G
Supplier:
Thermo Scientific Chemicals
Description:
Grade: 97, Melting Point C. Boiling Point C: 67-68*/50mm. C6H8O. 1679-36-3. FLAMMABLE
Catalog Number:
(76084-282)
Supplier:
Bioss
Description:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.
Catalog Number:
(102668-250)
Supplier:
Matrix Scientific
Description:
2-[3-(1H-Imidazol-2-yl)propyl]-1H-isoindole-1,3(2H)-dione
Supplier:
AMBEED, INC
Description:
5-Aminopyrimidin-4(3H)-one 97%
Catalog Number:
(100272-502)
Supplier:
Indofine Chemical Company
Description:
Fluoro Organics 1gm 459.98 Room temperature. 97%.
Catalog Number:
(102892-622)
Catalog Number:
(101790-414)
Supplier:
Matrix Scientific
Description:
MF=C4H8N2S MW=116.19 Cas=2055-46-1 MDL=MFCD00060526 25G
Supplier:
AMBEED, INC
Description:
(R)-5-Methylpyrrolidin-2-one ≥98%
Catalog Number:
(101826-742)
Supplier:
Matrix Scientific
Description:
1-Butyl-1H-indole-3-carbaldehyde
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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