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DIAGNOSTIC+BIOSYSTEMS+INC
Supplier:
Diagnostic Biosystems
Description:
This pan actin is useful in identifying tumors arising from muscle cells, i.e., leiomyosarcoma as well as rhabdomyosarcoma.
Catalog Number:
(89367-384)
Supplier:
Genetex
Description:
Calretinin is a 29 kDa calcium binding protein that is expressed in central and peripheral nervous system and in many normal and pathological tissues. Calretinin is also considered an important diagnostic aid in the differential diagnosis of cystic and solid ameloblastic tumors. The rat and human calretinin exhibit 98% sequence homology and 91% homology to many other species. Calretinin is generally expressed with two other calcium binding proteins Calbindin D-29 and parvalbumin in CNS and other peripheral tissues. Two calcium-binding proteins, calbindin and calretinin, have been reported to be expressed in abundance in Purkinje cells and other cell types in the cerebellum. The antibodies against calretinin also labels the mossy fibers throughout, and climbing fibers in a distinct group of folia. They also stain several cell types in the molecular layer. There is no appreciable immunostaining of calretinin in cerebellar cortex. In the rat, antibodies against calretinin stain the Lugaro cells, and some granule cells in lobe X; they also give weak staining of all the granule cells in the other lobes. Calretinin antibodies have been used to detect a number of carcinomas by clinicopathological, immunohistochemical techniques including, epithelial malignant mesotheliomas, Ovarian yolk sac tumor, Adenomatoid tumors of the uterus etc.
Supplier:
Biotium
Description:
This antibody recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
This MAb reacts with a 58 kDa protein identified as vimentin. It shows no cross-reaction with other closely related intermediate filament proteins (IFP's) such as desmin, keratin, neurofilament, and glial fibrillary acid protein.Anti-vimentin alone is of limited value as a diagnostic tool; however, when used in panels with other antibodies, it is useful for the sub-classification of a given tumor. Expression of vimentin, when used in conjunction with anti-keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and Schwannomas react strongly with anti-vimentin. It labels a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. Non-reactivity of anti-vimentin is often considered more useful than its positive reactivity, since there are a few tumors that do not contain vimentin, e.g. hepatoma and seminoma. Anti-vimentin is also useful as a tissue process control reagent.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Diagnostic Biosystems
Description:
Anti-Wilm's Tumor wt1 Mouse Monoclonal Antibody [clone: 6F-H2]
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a protein of 110 kDa, identified as androgen receptor
Catalog Number:
(76634-622)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with chains of human IgG. Nonspecific antibodies have been removed by solid-phase adsorption.
Catalog Number:
(76634-256)
Supplier:
Diagnostic Biosystems
Description:
This pan actin is useful in identifying tumors arising from muscle cells, i.e., leiomyosarcoma as well as rhabdomyosarcoma.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with α-chains of human IgA. This antibody has been adsorbed to a very high level of specificity.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to erythroid cells at various stages of differentiation from the erythroblast to the mature red cell.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes.
Catalog Number:
(76634-620)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with chains of human IgA. This antibody has been adsorbed to a very high level of specificity.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with herpes simplex virus type 2. It is specific for the viral glycoprotein D (gD) protein.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with human myeloperoxidase. It stains granules of neutrophils, granulocytes in spleen, bone marrow, tonsil and blood smears.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the mu-chains of human IgM. Nonspecific antibodies have been removed by solid-phase adsorption.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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