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Deuterium+oxide
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Deuterium+oxide
Catalog Number:
(10298-456)
Supplier:
Bioss
Description:
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
Catalog Number:
(76081-860)
Supplier:
Bioss
Description:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Catalog Number:
(10342-330)
Supplier:
Bioss
Description:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Catalog Number:
(10750-996)
Supplier:
Prosci
Description:
IDH2 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.
Catalog Number:
(89141-368)
Supplier:
Enzo Life Sciences
Description:
Adipose tissue is the source for a variety of bioactive molecules that regulate metabolism and immunity termed adipokines, most of which are elevated in the circulation of obese individuals. Adiponectin functions as an insulin sensitizing factor, resulting in reduced hepatic glucose production, increased glucose uptake in the muscle, and increased fatty acid oxidation in the liver and muscle. In contrast to most adipokines, adiponectin is detected at high levels in normal human plasma, but is often reduced in obese subjects and in those with increased insulin resistance and type 2 diabetes. Due to its suggested protective role in insulin resistance, adiponectin may be a useful pharmacological target for various metabolic diseases.
Supplier:
Thermo Scientific Chemicals
Description:
99.9% (REO).Powder,WARNING: Irritates skin, eye, lungs; affects blood clotting,25g,5g.
Catalog Number:
(BT217235-1KG)
Supplier:
BeanTown Chemical
Description:
CAS: 6834-92-0; EC No: 229-912-9; MDL No: MFCD00003492; RTECS: VV9275000
UN No: UN3253; Haz Class: 8; Packing Group: III
-18 Mesh Granular; Linear Formula: Na2SiO3; MW: 122.06
Melting Point: 1090°
Density (g/mL): 2.61
Catalog Number:
(10320-644)
Supplier:
Bioss
Description:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Catalog Number:
(10320-642)
Supplier:
Bioss
Description:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Catalog Number:
(10320-640)
Supplier:
Bioss
Description:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Catalog Number:
(10342-112)
Supplier:
Bioss
Description:
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Supplier:
BeanTown Chemical
Description:
CAS: 25322-68-3; EC No: 203-473-3; MDL No: MFCD00081839; RTECS: TQ4110000
Flakes; Linear Formula: H(OCH2CH2)nOH; MW ≈10,000
Melting Point: 63-65°; Flash point: 265°C (509°F)
Catalog Number:
(10752-178)
Supplier:
Prosci
Description:
ME1, also known as NADP-ME, MES or HUMNDME, may play an important role as a housekeeping protein within the cell. ME1 is a 572 amino acid cytoplasmic protein that belongs to the malic enzyme family. It is expressed ubiquitously with highest expression in liver and white adipose tissue. ME1 functions as an NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. ME1 is regulated by both thyroid hormone levels and the amount of carbohydrates in the diet.
Catalog Number:
(89298-322)
Supplier:
Genetex
Description:
Goat polyclonal antibody to NOS1
Catalog Number:
(10229-218)
Supplier:
Bioss
Description:
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
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