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(2R,2\'R)-4,4\'-Disulfanediylbis(2-aminobutanoic+acid)
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(2R,2\'R)-4,4\'-Disulfanediylbis(2-aminobutanoic+acid)
Supplier:
MP Biomedicals
Description:
Dimethyl Pimelimidate Dihydrochloride is a bifunctional cross linking reagent used in peptide research.
Catalog Number:
(IC10247101)
Supplier:
MP Biomedicals
Description:
p-Nitrophenyl-alpha-D-galactopyranoside is used as a substrate for α-galactosidase.
Supplier:
MP Biomedicals
Description:
Acrylamide is a monomer used in a variety of synthetic processes to form polymers and copolymers. It polymerizes in the presence of free radicals in aqueous solutions. It is usually used to prepare polyacrylamide gels for electrophoresis separation of biomolecules.
Supplier:
MP Biomedicals
Description:
2-Hydroxypropyl-beta-cyclodextrin are non-toxic solubilisers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states.
Supplier:
MP Biomedicals
Description:
Butylated Hydroxyanisole is an antioxidant. It is a mixture of 2- and 3-tertiary-butyl-4-hydroxyanisole.
Catalog Number:
(76009-392)
Supplier:
Prosci
Description:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Supplier:
Adipogen
Description:
Key metabolite of the ketolytic pathway generating acetyl-CoA. Stereoselective product of D-3-hydroxybutyrate dehydreogenase. Clinically and physiologically significant stereoisomer. Energy carrier from adipocytes to peripheral tissues during fasting or exercise. Endogenous inhibitor of histone deacetylases (HDACs) 1, 3 and 4. Ligand of free fatty acid receptor 3 (FFAR3; GPR41) and hydroxycarboxylic acid receptor 2 (HCAR2; GPR109B). NLRP3 inflammasome inhibitor. Prevents K+-efflux and reduces ASC oligomerization and speck formation.
Supplier:
MP Biomedicals
Description:
Conduritol B Epoxide (CBE) is a potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase, specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside.
Supplier:
Adipogen
Description:
Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 (IL-10) and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.
Supplier:
Thermo Scientific Chemicals
Description:
A monoamine oxidase inhibitor; inhibits platelet aggregation
Supplier:
MP Biomedicals
Description:
Vincristine Sulfate, a dimeric Vinca alkaloid. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses.
Supplier:
MP Biomedicals
Description:
Bromocresol Purple is used as a pH indicator (5.2-6.8 : yellow to blue-purple). Used in spectrophotometric determination of serum-albumin.
Catalog Number:
(77402-268)
Supplier:
APOLLO SCIENTIFIC
Description:
4-(Dimethylamino)benzyl alcohol 97%
Supplier:
Thermo Scientific Chemicals
Description:
Extensively used in cancer research
Catalog Number:
(RK30212)
Supplier:
Restek
Description:
Mix contains: Bromodichloromethane (75-27-4); Bromoform (75-25-2); Carbon tetrachloride (56-23-5); Chlorobenzene (108-90-7); 2-Chloroethyl vinyl ether (110-75-8); Chloroform (67-66-3); Dibromochloromethane (124-48-1); 1,2-Dichlorobenzene (95-50-1); 1,3-Dichlorobenzene (541-73-1); 1,4-Dichlorobenzene (106-46-7); 1,1-Dichloroethane (75-34-3); 1,2-Dichloroethane (107-06-2); 1,1-Dichloroethene (75-35-4); trans-1,2-Dichloroethene (156-60-5); 1,2-Dichloropropane (78-87-5); cis-1,3-Dichloropropene (10061-01-5); trans-1,3-Dichloropropene (10061-02-6); Methylene chloride (dichloromethane) (75-09-2); 1,1,2,2-Tetrachloroethane (79-34-5); Tetrachloroethene (127-18-4); 1,1,1-Trichloroethane (71-55-6); 1,1,2-Trichloroethane (79-00-5); Trichloroethene (79-01-6).
Supplier:
MP Biomedicals
Description:
Retinol is one of the animal forms of vitamin A. It is a diterpenoid and an alcohol.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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