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Dibutyryl-cGMP
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Dibutyryl-cGMP
Catalog Number:
(10300-330)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
Supplier:
Spectrum Chemicals
Description:
Cetostearyl Alcohol, NF is used as a stabilizer and opacifying agent.Â
Supplier:
Spectrum Chemicals
Description:
Riboflavin, FCC is also referred to as vitamin B2 and used as a dietary supplement. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Supplier:
Spectrum Chemicals
Description:
Ferrous Fumarate, USP is a mineral supplement.Â
Supplier:
Spectrum Chemicals
Description:
Benzoic Acid, FCC is used as a food preservative inhibiting the growth of mold, yeast and some bacteria. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Supplier:
Spectrum Chemicals
Description:
Biotin, Powder, USP is a water-soluble B vitamin.Â
Supplier:
Spectrum Chemicals
Description:
BISMUTH CITRATE, POWDER, USP is used as an internal deodorant and treats malodor by deodorizing flatulence and stool odors. It is usually given to people who suffer from fecal incontinence, IBS or who have has ostomy surgery or bariatric surgery. Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Storage temperature - LIGHT SENSITIVE: Keep tightly closed in light-resistant containers.
Supplier:
Spectrum Chemicals
Description:
Ferric Subsulfate Solution, USP.Â
Supplier:
Spectrum Chemicals
Description:
Hydroxypropyl Cellulose, 4,000-6,500 cP, NF is a non-ionic, water soluble polymer used as a thickening agent and gelling agent for aqueous formulations.Â
Supplier:
Spectrum Chemicals
Description:
Sodium Polyphosphates, Glassy, FCC is used as an acidity regulator, emulsifier and buffering agent, and as a sequestering agent. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Supplier:
Spectrum Chemicals
Description:
Ibuprofen, USP is a non-steroidal anti-inflammatory drug often used to treat and reduce fevers and swelling. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Supplier:
Spectrum Chemicals
Description:
Hypromellose, Substitution Type 2208, 100,000 mPa.s, USP.Â
Supplier:
Spectrum Chemicals
Description:
Calcium Gluconate, Anhydrous, Powder, USP is used as a nutrient. All Spectrum Chemical USP grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Supplier:
Adipogen
Description:
Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor. Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis. Enhances differentiation of 3T3-L1 cells. Non-selective adenosine receptor antagonist. Inhibits Ca2+ ion channels. Activates TNF-alpha. Adipogenic. Activates leukotriene synthesis. Reduces inflammation and innate immunity.
Catalog Number:
(76009-706)
Supplier:
Prosci
Description:
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.
Supplier:
Spectrum Chemicals
Description:
Magnesium Oxide, Heavy Powder, USP has many uses, but from a pharmaceutical perspective it is used primarily as a mineral supplement and a tablet and capsule diluent.Â
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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