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H-d-Ser(tBu)-OMe·HCl
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H-d-Ser(tBu)-OMe·HCl
Catalog Number:
(10325-936)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
Catalog Number:
(103623-724)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the human GLT25D2 (Q8IYK4) (Met 1-Ser 622) was fused with a polyhistidine tag at the C-terminus.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human CD27 Ligand / CD70 Protein, Fc Tag (active trimer) (MALS verified), ACROBiosystems
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human CD73 Protein, Mouse IgG2a Fc Tag (active enzyme), ACROBiosystems
Catalog Number:
(103617-350)
Supplier:
Sino Biological
Description:
This antibody was obtained from a rabbit immunized with purified, recombinant Human TGF-beta 1 (rh TGF-beta 1; Catalog#10804-H08H; NP_000651.3; Met 1-Ser 390).
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Mouse ErbB3 / Her3 Protein, His Tag, ACROBiosystems
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Human BTLA (31-150) Protein, Mouse IgG2a Fc Tag, ACROBiosystems
Catalog Number:
(103618-538)
Supplier:
Sino Biological
Description:
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-10 (rh IL-10; Catalog#10947-HNAE; NP_000563.1; Ser 19-Asn 178).
Catalog Number:
(103619-096)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Human CD16b (rhCD16b; Catalog#11046-H08H; O75015.2; Met 1-Ser 200). Total IgG was purified by Protein A affinity chromatography.
Catalog Number:
(10333-764)
Supplier:
Bioss
Description:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Catalog Number:
(103664-970)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the extracellular domain of mouse TNFRSF10B (NP_064671.2) (Met 1-Ser 177) was expressed, with a C-terminal polyhistidine tag.
Catalog Number:
(10478-980)
Supplier:
Bioss
Description:
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Supplier:
AMBEED, INC
Description:
TRIS HCl (tris(hydroxymethyl)aminomethane hydrochloride) 98%
Catalog Number:
(76120-648)
Supplier:
Bioss
Description:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
Supplier:
Promega Corporation
Description:
Recombinant full-length human JNK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at the thr and tyr residues during exposure to stress.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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