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4-Chloro-1-ethyl-1H-pyrazole
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4-Chloro-1-ethyl-1H-pyrazole
Supplier:
Adipogen
Description:
Highly reactive, thiol-specific spin-label. Specific conformational probe of thiol site structure by its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study. Used to label cysteine residues in proteins (site-directed labeling, SDS-labeling). Allows protein structure and protein dynamics determination as well as the study of protein-protein and protein-oligonucleotide interactions.
Supplier:
Adipogen
Description:
Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively).
Supplier:
TCI America
Description:
CAS Number: 1517-69-7
MDL Number: MFCD00064263 Molecular Formula: C8H10O Molecular Weight: 122.17 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 89 Melting point (°C): 11 Flash Point (°C): 86 Specific Gravity (20/20): 1.01
Supplier:
MP Biomedicals
Description:
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Supplier:
Adipogen
Description:
Anti-inflammatory and anti-arthritic agent
Supplier:
Agilent Technologies
Description:
The RecoverEase DNA isolation kit recovers high-molecular-weight (100 to 500 kb) genomic DNA that is fully hydrated and ready for multiple applications the next day. DNA can be isolated from whole tissues such as liver, spleen, kidney, brain and testes without hazardous and tedious organic extractions or ethanol precipitations. The RecoverEase DNA isolation kit quickly isolates high-molecular-weight genomic DNA from a variety of tissues without organic solvent extractions or ethanol precipitation;
Catalog Number:
(AAJ63784-EXG)
Supplier:
Thermo Scientific Chemicals
Description:
This leptomycin B is a potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus.
Catalog Number:
(10282-058)
Supplier:
Bioss
Description:
ADH6 (alcohol dehydrogenase 6), also known as ADH-5, is a 368 amino acid member of the class V zinc-containing alcohol dehydrogenase family. This family of enzymes functions to metabolize a wide variety of substrates such as retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and expressed in the stomach and liver, ADH6 catalyzes the reversible oxidation of alcohols to their corresponding aldehydes or ketones and is able to bind two zinc ions as cofactors. ADH6 contains a glucocorticoid response element upstream of its 5' UTR which is thought to be a steroid binding site, suggesting that expression of ADH6 may be under hormonal control. Multiple isoforms of ADH6 exist due to alternative splicing events.
Supplier:
TCI America
Description:
CAS Number: 134-84-9
MDL Number: MFCD00008553 Molecular Formula: C14H12O Molecular Weight: 196.25 Purity/Analysis Method: >95.0% (GC) Form: Crystal Boiling point (°C): 328 Melting point (°C): 56 Flash Point (°C): 143
Catalog Number:
(10282-056)
Supplier:
Bioss
Description:
ADH6 (alcohol dehydrogenase 6), also known as ADH-5, is a 368 amino acid member of the class V zinc-containing alcohol dehydrogenase family. This family of enzymes functions to metabolize a wide variety of substrates such as retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and expressed in the stomach and liver, ADH6 catalyzes the reversible oxidation of alcohols to their corresponding aldehydes or ketones and is able to bind two zinc ions as cofactors. ADH6 contains a glucocorticoid response element upstream of its 5' UTR which is thought to be a steroid binding site, suggesting that expression of ADH6 may be under hormonal control. Multiple isoforms of ADH6 exist due to alternative splicing events.
Catalog Number:
(10282-026)
Supplier:
Bioss
Description:
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans.
Catalog Number:
(10282-044)
Supplier:
Bioss
Description:
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. ADH5 (alcohol dehydrogenase 5 (class III)), also known as FDH (formaldehyde dehydrogenase), ADHX, ADH-3 or GSNOR, is a 374 amino acid cytoplasmic protein that belongs to the class III subfamily of alcohol dehydrogenases. Expressed ubiquitously, ADH5 uses iron as a cofactor to catalytically oxidize both long-chain primary alcohols and S-hydroxymethyl-glutathione, a product formed spontaneously between formaldehyde and glutathione. ADH5 exists as a homodimer and, via its ability to oxidize S-hydroxymethyl-glutathione and, thus, eliminate formaldehyde, functions as an important component of cellular metabolism. Genetic variations in the gene encoding ADH5 may affect drug and alcohol dependence in humans.
Supplier:
Adipogen
Description:
Brivanib inhibits VEGFR-2 with an IC(50) of 25nM and a Ki of 26nM, VEGFR-1 with an IC(50) of 380nM and VEGFR-3 with an IC(50) of 10nM. It also shows selectivity for FGFR-1 with an IC(50) of 148nM, FGFR-2 with an IC(50) of 25nM and FGFR-3 with an IC(50) of 68nM.
Supplier:
Adipogen
Description:
Erlotinib inhibits EGFR tyrosine kinase auto-phosphorylation. Studies in cell lines and enzyme assays have shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl. It has an IC(50) of 2nM against EGFR. It is <gt/>1000-fold more sensitive for EGFR than for c-Src or v-Abl.
Supplier:
Adipogen
Description:
AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family.
Supplier:
Adipogen
Description:
Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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