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Nickel(II)+p-toluenesulfonate
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Nickel(II)+p-toluenesulfonate
Catalog Number:
(10106-944)
Supplier:
Prosci
Description:
RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. RFX is a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
Supplier:
Bachem Americas
Description:
See also the product families 'Adjuvant Peptides' and 'Thymosins and Fragments'.
Catalog Number:
(10800-082)
Supplier:
Rockland Immunochemical
Description:
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.
Supplier:
BeanTown Chemical
Description:
CAS: 13600-98-1; EC No: 237-077-7; MDL No: MFCD00003512
UN No: UN1479; Haz Class: 5.1; Packing Group: II
Powder; Linear Formula: Na3Co(NO2)6; MW: 403.94
Melting Point: 220° (decomposes)
Supplier:
BeanTown Chemical
Description:
CAS: 21109-95-5; EC No: 244-214-4; MDL No: MFCD00014192
UN No: UN2813; Haz Class: 4.3; Packing Group: II
-200 Mesh Powder ; Molecular Formula: BaS ; MW: 163.39
Density (g/mL): 4.25
Moisture Sensitive
Supplier:
Enzo Life Sciences
Description:
Slow-binding competitive inhibitor of arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation.
Catalog Number:
(10107-342)
Supplier:
Prosci
Description:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually
Catalog Number:
(10102-480)
Supplier:
Prosci
Description:
LAMP3 might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer.
Supplier:
BeanTown Chemical
Description:
CAS: 1694-92-4; EC No: 216-907-1; MDL No: MFCD00007430
UN No: UN3261; Haz Class: 8; Packing Group: II
Crystalline; Molecular Formula: C6H4ClNO4S ; MW: 221.62
Melting Point: 63-67°
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 98-74-8; EC No: 202-697-9; MDL No: MFCD00007445
UN No: UN3261; Haz Class: 8; Packing Group: II
Powder; Molecular Formula: C6H4ClNO4S; MW: 221.62
Melting Point: 66-70°
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 70197-13-6; MDL No: MFCD00192332
UN No: UN1479; Haz Class: 5.1; Packing Group: II
Crystalline; Linear Formula: CH3ReO3; MW: 249.24
Melting Point: 110-115°
Light Sensitive, Moisture Sensitive
Catalog Number:
(10472-080)
Supplier:
Bioss
Description:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Supplier:
BeanTown Chemical
Description:
CAS: 14002-51-8; EC No: 237-804-8; MDL No: MFCD00000692
UN No: UN3261; Haz Class: 8; Packing Group: II
Powder; Molecular Formula: C13H9ClO; MW: 216.66
Melting Point: 110-112°
Moisture Sensitive
Catalog Number:
(76119-936)
Supplier:
Bioss
Description:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Catalog Number:
(10472-032)
Supplier:
Bioss
Description:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Catalog Number:
(10472-034)
Supplier:
Bioss
Description:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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