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4-(2-Propynyloxy)benzenecarbaldehyde
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4-(2-Propynyloxy)benzenecarbaldehyde
Catalog Number:
(102987-178)
Supplier:
Adipogen
Description:
Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization.
Catalog Number:
(103645-792)
Supplier:
Sino Biological
Description:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CSF1R / MCSF Receptor / CD115 (rh CSF1R / MCSF Receptor / CD115; Catalog#10161-H08H; NP_005202.2; Met1-Glu512). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Catalog Number:
(102882-796)
Supplier:
R&D Systems
Description:
Mouse CD3 PerCP, Monoclonal, Host: Rat, Clone NO: 17A2, Isotype: IgG2B, Immunogen: T cell hybridoma D1, Flow Cytometry, 25 Tests
Catalog Number:
(89162-048)
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome.A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (now referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing.
Supplier:
Justrite
Description:
Specially designed for safely storing acids and corrosives in laboratories.
Supplier:
Honeywell Research Chemicals
Description:
2,2,4-Trimethylpentane, Purity: >/= 99.5 % by Gas Chromatography, Grade: Puriss. P.a, Container Type: Glass Bottle, Alternate name: Isooctane, Size: 2.5 l
Supplier:
DWK Life Sciences (KIMBLE)
Description:
Designed to adapt a variety of tubes, condensers and filters in 14/20 and 24/25–24/40 glassware.
Catalog Number:
(102882-590)
Supplier:
R&D Systems
Description:
Human CD4 Phycoerythrin, Monoclonal, Host: Mouse, Clone NO: 11830, Isotype: IgG2A, Immunogen: Recombinant Human CD4. Flow Cytometry, 25 Tests
Catalog Number:
(RC2230.025-16)
Supplier:
Ricca Chemical
Description:
APHA / Hazen (Platinum-Cobalt), Color = 25 units. APHA, ASTM, ACS, EPA. Stock platinum-cobalt formula. Amber glass bottle. 500mL.
Supplier:
TCI America
Description:
CAS Number: 57044-25-4
MDL Number: MFCD00074873 Molecular Formula: C3H6O2 Molecular Weight: 74.08 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 57 Flash Point (°C): 72 Specific Gravity (20/20): 1.12 Specific rotation [a]20/D: 15 deg (neat) Storage Temperature: <0°C
Catalog Number:
(10800-032)
Supplier:
Rockland Immunochemical
Description:
GAB1 antibody detects GAB1 which is a member of the IRS1-like multisubstrate docking protein family. The protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. GAB1 plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. It is known to play a role in FGFR1 signaling and is probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). GAB1 interacts with GRB2 and with other SH2-containing proteins. It is known to interact with phosphorylated LAT2, PTPRJ, FRS2, GRB2, PIK3R1 and SOS1. GAB1 gets phosphorylated in response to FGFR1 activation. This tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Anti-GAB1 Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience and Signal Transduction research.
Supplier:
Thermo Scientific Chemicals
Description:
3,4-Dimethyl-2,5-furandione. Grade: 97. Melting Point C93-96*. Boiling Point C: 222-223*. C6H6O3. 766-39-2. IRRITANT MOISTURE SENSITIVE
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Mouse Recombinant M-CSF R (from HEK293)
Supplier:
CP Lab Safety
Description:
ECO Funnel® is the ultimate lab safety product for collection of hazardous liquid waste. When securely attached onto an open waste container, it prevents 99.9% of toxic fumes from being released into lab. ECO Funnel is designed to prevent fires caused by ignited vapors as well as spills of hazardous waste from open containers, which helps laboratories stay compliant with local health and safety codes.
Catalog Number:
(89162-052)
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. Based on sequence similarity, all fourteen 20S proteasomal subunit sequences may be classified into two groups, α and β, each group having distinct structural and functional roles. The α-subunits comprise the outer rings and the β-subunits the inner rings of the 20S proteasome. Observations of the eukaryotic proteasome and analysis of subunit sequences indicate that each ring contains seven different subunits (α7β7β7α7) with a member of each sub-family represented in each particle. Each subunit is located in a unique position within the α- or β-rings. 120S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The hybridoma secreting the antibody to subunits HC2, HC3, HC8, HC9, Iota and Zeta was generated by fusion of spenocytes from Balb/c mice which had recieved repeated immunisation with dinitrophenylated proteasomes.
Catalog Number:
(RLD306)
Supplier:
Rockland Immunochemical
Description:
All lyophilized control sera comes in 5 mL vials.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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