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Sodium+methotrexate
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Sodium+methotrexate
Catalog Number:
(77982-857)
Supplier:
LGC STANDARDS
Description:
rac 3,4-Dihydroxymandelic Acid, TRC, LGC Standards
Supplier:
Biolegend
Description:
CD56 (NCAM) Recombinant Monoclonal Antibody, host: Mouse, Clone: QA18A21, Reactivity: Human, Isotype: IgG1, K, Conjugate: PE, Formulation: Phosphate-buffered solution, containing 0.09% sodium azide, Application: FC, Synonyms: Leu-19, NKH1, Size: 100 tests
Catalog Number:
(76117-970)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Catalog Number:
(10433-840)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Catalog Number:
(10433-822)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Supplier:
AAT BIOQUEST INC
Description:
WST-8 (2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) is a water-soluble tetrazolium salt used for assessing cell metabolic activity.
Catalog Number:
(10429-698)
Supplier:
Bioss
Description:
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Catalog Number:
(TCT0050-025G)
Supplier:
TCI America
Description:
CAS Number: 18472-87-2
MDL Number: MFCD00070627 Molecular Formula: C20H4Br4Cl4O5 Molecular Weight: 829.63 Purity/Analysis Method: >85.0% (E) Form: Crystal Color: Deep Yellow Red Lambda max.: 538 nm (0.02mol/L AcONH4 sol.)
Supplier:
Biolegend
Description:
CD133, Monoclonal Antibody, Clone: S16016B, Host: Mouse, Species Reactivity: Human, Isotype: IgG2a, K, Conjugate: APC, Immunogen: Human CD133 transfectants, Other Names: Prominin-1, PROM1, Formulation: Phosphate-buffered solution, 0.09% sodium azide and 0.2% BSA, Size: 25 Tests
Supplier:
Biolegend
Description:
GPR183, Monoclonal Antibody, Clone: SA313E4, Host: Mouse, Species Reactivity: Human, Isotype: IgG2a, K, Conjugate: PerCP/Cyanine5.5, Immunogen: Human GPR183-transfected cells, Other Names: EBI2, Formulation: Phosphate-buffered solution, 0.09% sodium azide 0.2% BSA, Size: 25 Tests
Catalog Number:
(76422-790)
Supplier:
Biolegend
Description:
CD94 Monoclonal Antibody, Clone: 18d3, Host: Rat, Species: Mouse, Isotype: IgG2a, K, Conjugate: TotalSeq A1009, Immunogen: CHO cell expressing the C57BL/6 alleles of CD94 and NKG2A, Formulation: Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, Synonyms: Kp43, Application: FC, Size: 10ug
Catalog Number:
(10061-718)
Supplier:
Prosci
Description:
16 amino acids near the carboxy terminus of human TRPV1.
Catalog Number:
(10108-564)
Supplier:
Prosci
Description:
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. SLC13A3 represents the high-affinity form.Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
Catalog Number:
(95043-558)
Supplier:
G-Biosciences
Description:
(20mM Sodium phosphate, 0.15m NaCl, pH 7.5), 100ml
Catalog Number:
(76422-350)
Supplier:
Biolegend
Description:
TCR A/B Monoclonal Antibody, host: Mouse, Clone: IP26, Reactivity: Human, Isotype: IgG1, K, Conjugate: PE, Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide, 0.2% (w/v) BSA (origin USA), and a stabilizerConcentration: 200 ug/mL, Size: 500ul
Supplier:
MP Biomedicals
Description:
Hanks' Balanced Salts solution is used to maintain the pH and osmotic balance in the medium and to provide the cells with water and essential inorganic ions.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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