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DIAGNOSTIC BIOSYSTEMS INC
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DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 33 kDa polypeptide present on the majority of B cells in peripheral blood and lymphoid tissue. No reactivity with other hematopoietic cells has been observed.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts specifically with CA 125 ovarian cancer antigen
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as plasmacytoid T cells.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.
Supplier:
Diagnostic Biosystems
Description:
This buffer is a concentrated antigen unmasking solution and is free from heavy metals
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.
Supplier:
Diagnostic Biosystems
Description:
The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 100 kDa glycoprotein expressed by endothelial cells and 130 kDa glycoprotein present in platelets. It stains endothelial cells in normal as well as malignant tissues.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with human isoenzymes of neuron specific enolase containing γ subunits. This antibody gives a specific staining in neurons of the brain, in islets of Langerhans in pancreas and in peripheral nerves of the skin. No staining with other tissue types has been seen.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes cytokeratin polypeptides ranging from 40 through 58kDa, corresponding to cytokeratins 5, 6, 8,17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia, like epidermis, mammary gland ducts and tracheal epithelium.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.
Catalog Number:
(10065-004)
Supplier:
Diagnostic Biosystems
Description:
PAX 8 is expressed in a high percentage of renal cell carcinomas and ovarian cancers. This mouse monoclonal PAX 8 antibody [BC12] has been designed to target restricted epitopes, and exhibits higher specificity and provides sharper staining than the PAX 8 rabbit polyclonal antibody. Unlike the polyclonal PAX 8, this mouse monoclonal antibody does not stain B-cells, and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon; thus providing superior specificity. The expression of the mouse monoclonal PAX 8 targets antigens found in normal kidney, thyroid and cervix, but not normal ovary. PAX 8 stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.
Catalog Number:
(76633-186)
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.
Catalog Number:
(76634-402)
Supplier:
Diagnostic Biosystems
Description:
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to two proteins of 185 kDa and 145 kDa, identified as two isoforms of neural cell adhesion molecules (NCAM/CD56). NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma and neuroblastoma.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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